conformational change

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13:01 Apr 27, 2009
English to Arabic translations [PRO]
Science - Biology (-tech,-chem,micro-)
Additional field(s): Genetics
English term or phrase: conformational change
Definition from Biochemical Society:
Large, medium or small adjustment to the molecular shape/dynamics of a protein that may follow a change in environment or the specific recognition of another molecule.

Example sentence(s):
  • These observations indicate that heparin, in addition to causing aggregation, also induces a conformational change in tau in which reactive groups are unmasked or move closer leading to the DSS cross-linking of 72- and 83-kDa species. jbc online
  • At low pH, the hemagglutinin (HA) of influenza virus undergoes an irreversible conformational change that potentiates its essential membrane fusion function. The Rockefeller University Press
  • To develop the antibody chip for detecting the Bax conformational change, we immobilized Bax monoclonal antibody 6A7, which recognizes only a conformationally changed Bax protein on a gold surface. Elsevier Inc.
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Summary of translations provided
5التبدلات الشكلية
aalkoky
5تغير في الشكل الفراغي
Ehab Tantawy
5التغير التركيبي
Dr. Mohamed Elkhateeb
5التغير الشكلي
Fahd Hassanein
5التغير الشكلي
RA_translato (X)
4التغيير المعدل
Shazly


  

Translations offered


4 hrs   confidence: Answerer confidence 5/5
التبدلات الشكلية


Definition from own experience or research:
التغيرات الشكلية

Example sentence(s):
aalkoky
Native speaker of: Native in ArabicArabic
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تغير في الشكل الفراغي


Definition from own experience or research:
conformation
■ noun the shape or structure of something. ▶Chemistry any of the spatial arrangements which the atoms in a molecule may adopt, especially by rotation about individual single bonds.


conformational adjective


C16: from L. conformatio(n-), from conformare (see conform).

© Oxford University Press, 2004
===

con·for·ma·tion
Pronunciation: ˌkän-(ˌ)fȯr-'mā-shən, -fər-
Function: noun
Date: 1511

1 : the act of conforming or producing conformity : ADAPTATION
2 : formation of something by appropriate arrangement of parts or elements : an assembling into a whole <the gradual conformation of the embryo>
3 a : correspondence especially to a model or plan b : STRUCTURE c : the shape or proportionate dimensions especially of an animal d : any of the spatial arrangements of a molecule that can be obtained by rotation of the atoms about a single bond
–con·for·ma·tion·al -shnəl, -shə-nəl adjective

© 2005 Merriam-Webster, Incorporated

Example sentence(s):
  • STRUCTURE c : the shape or proportionate dimensions especially of an animal d : any of the spatial arrangements of a molecule that can be obtained by rotation of the atoms about a single bond - Merriam-Webster, Incorporated  
Ehab Tantawy
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التغير التركيبي


Definition from own experience or research:
التغير التركيبي هو التغير في شكل جزيء البروتين وهو يمكن أن يكون تغير كبير أو متوسط أو صغير.

Example sentence(s):
  • جـ- التغيّر التركيبي Conformational change هذه الميكانيكية تقترح أن الأنزيم أو البروتين الناقل في الأحوال العادية (عدم قيامه بالنقل) يأخذ وضع تركيبي محدد في الغشاء البلازمي ولكن عند ارتباطه بالمادة المنقولة فإن الشكل التركيبي له يتغير ويؤدي هذا التغير إلى نقل المادة إلى داخل الخلية أو إلى خارجها حسب نوع الأنزيم أو البروتين الناقل. - علم الخلية-الباب الخا�  

Explanation:
يكون التغير التركيب راجعا لتغير البيئة عادة
Dr. Mohamed Elkhateeb
Egypt
Local time: 07:26
Native speaker of: Arabic
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التغير الشكلي


Definition from own experience or research:
هو تغير شكل وهيئة الجزيء ناتج عن تغير في البيئة المحيطة كتغير درجة الحرارة وهو تغير في الهيئة والتوزيع الفراغي للجزيء لا في التركيب الكيميائي.

Example sentence(s):
  • البنية البروتينية غير ثابتة إطلاقا بل تتغير لتأدية وظائفها المختلفة و لتحقيق هذا التغيير البنيوي يحدث تغير في ارتباطات البنية الثالثية و الرابعية ، لذلك ندعو هذه البنى الثالثية و الرابعية تشكيلات كيميائية و ما يحدث لها من تغيرات بالتغيرات التشكيلية conformational changes . - Wikipedia  
Fahd Hassanein
Türkiye
Local time: 08:26
Native speaker of: Native in ArabicArabic
PRO pts in category: 17
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التغيير المعدل


Definition from Wikipedia:
Conformational change
A macromolecule is usually flexible and dynamic. It can change its shape in response to changes in its environment or other factors; each possible shape is called a conformation, and a transition between them is called a conformational change. A macromolecular conformational change may be induced by many factors such as a change in temperature, pH, voltage, ion concentration, or the binding of a ligand.

Example sentence(s):
  • التغيير المعدل/التغيير المعدل للجزيئ - Wikipedia  

Explanation:
التغيير المعدل/التغيير المعدل للجزيء
Shazly
Egypt
Local time: 07:26
Native speaker of: Native in ArabicArabic
PRO pts in category: 4
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التغير الشكلي


Definition from gerstein lab:
هو عبارة عن تغير يحدث لشكل جزيء البروتين نتيجة إما لتغير يطرأ في البيئة المحيطة به أو لارتباطه بجزئء معين آخر وقد يكون هذا التغيير كبيراً أو متوسطاً أو صغيراً.

Example sentence(s):
  • While these conformational changes can occur upon environmental changes such as varying pH and temperature levels, the majority of large conformational movements in the database take place upon the event of binding interactions between proteins, ligands, sugars, lipids, and/or small molecules. - gerstein lab  
  • Protein conformation is of paramount importance in understanding biomolecular interactions. In the simplest scenario, two molecules may interact with no change in their conformation, as in the key-and-lock model. Molecular interactions that involve conformational changes in the interacting molecules are more versatile. - Department of Biological Sci at Birkbeck  
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