Window of Opportunity Study
| 22:28 Apr 5, 2012 |
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| English to Dutch translations [PRO] Medical - Medical (general) / Klinische onderzoeken | |||||||
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| 4 | studie naar spectrum van kansen/mogelijkheden |
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| 'definition' |
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Answers
7 hrs confidence: 
| window of opportunity study studie naar spectrum van kansen/mogelijkheden Explanation: Het is een algemeen zakelijk/wetenschappelijk gebruikte term om een periode/scala aan mogelijkheden (window) aan te geven waarin oplossing werkt of resultaat geboekt kan worden. Het omschrijft een beperking in tijd en/of omvang ('window') waarbinnen oplossingen of het gewenste resultaat kan worden gevonden/behaald. 1.zakelijk (zie 'Investorworld') Definition: A short period of time during which an opportunity must be acted on or missed. 2. wetenschappelijk (zie Master thesis Geowetenschappen) ....waarbij relevante partijen een bepaalde maatschappelijke ontwikkeling erkennen als probleem en er geschikte oplossingen voorhanden zijn..... Reference: http://www.investorwords.com/5323/window_of_opportunity.html Reference: http://igitur-archive.library.uu.nl/student-theses/2012-0116... |
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Reference comments
5 hrs peer agreement (net): +1 |
| Reference: 'definition' Reference information: met wat ik gevonden heb, snap ik niet hoe men komt aan 'kansbepalend gespreid onderzoek' window-of-opportunity trials / window trials / window of time het lijkt te gaan om een per definitie kortdurende (window) en daarnaast ook gunstige gelegenheid (opportunity) om de werkzaamheid van bepaalde soorten middelen te evalueren 'gunstige gelegenheid', zo lijkt het, omdat het middel wordt uitgetest op tumoren die niet eerder met andere middelen zijn behandeld: het werkelijk effect kan daardoor beter worden beoordeeld men grijpt zijn kans als het ware, nu kan het even, voordat wordt begonnen met de 'echte' behandeling Window-of-opportunity trials to evaluate clinical activity of new molecular entities in oncology Background: The introduction of molecular targeted agents (e.g. monoclonal antibodies or kinase inhibitors) and cancer vaccines has raised the question whether alternate clinical trial designs, including window trials, are better suited to evaluate such new molecular entities (NMEs) and improve their approval rates. In window trials, patients receive an NME for a window of time before starting standard treatment allowing the evaluation of an NME in tumors unperturbed by previous therapies. Methods: A systematic literature search was conducted to identify window trials in adult and pediatric oncology. Results: Twenty-nine window trials were identified and reviewed, 13 in pediatric and 16 in adult oncology. Most of the trials (20/29) tested cytotoxics known to have activity in other clinical situations. In contrast to trials with pretreated patients, the window trials established the antitumor activity of melphalan, topotecan, epirubicin and etoposide in untreated patients with rhabdomyosarcoma or small-cell lung cancer. In window trials with ineffective or modestly active NMEs, we found no indication of a significant negative effect on overall survival for participating patients. Conclusions: Provided close safety monitoring and careful patient selection, window trials are a safe option to investigate potential clinical activity of NMEs http://annonc.oxfordjournals.org/content/early/2011/01/13/an... "window of opportunity" trials represent another elegant way to elucidate the mechanism of action of a new drug by using the pre-operative setting (Ratain, 2010). This setting first allows administering a treatment to chemo-naive patients whose tumors have not developed tumor resistance due to previous therapies. Second, it brings a unique opportunity for translational research from tissue obtained from initial biopsy and from surgical resection specimen. In these trials, the new drug is classically administered for a short period of time, in order not to expose these potentially curable patients to disease progression. The primary endpoint in these trials should be a biological endpoint rather than a clinical activity endpoint that will likely not be met. This kind of trials requires a close collaboration between surgeons, medical oncologists and research teams. http://www.discoverymedicine.com/Jennifer-Arrondeau/2010/10/... (http://en.wikipedia.org/wiki/Translational_research) |
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18 hrs |
| Reference Reference information: Heb je dit bekeken, over "window studies"? http://is.gd/lhSN5A Kijk eens bij vensteronderzoek. Ik heb geen tijd om het verder uit te zoeken. |
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