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affinity maturation

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00:56 Oct 28, 2020
English to Dutch translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
4affiniteitsmaturatie
Erik van Vliet


  

Translations offered


3 days 11 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
affiniteitsmaturatie


Definition from Universiteit Utrecht:
Affiniteitsmaturatie een succesvolle rijping en selectie van B-cellen die antilichamen met een hoge affiniteit hebben. Affiniteitsmaturatie wordt gezien als maat voor een succesvolle inductie van memory B-cellen en dus immunologisch geheugen. Antigeen een stof die een immuunrespons opwekt.

Example sentence(s):
  • In de kiemcentra onstaan cycli van B-cel proliferatie en affiniteitsmaturatie gevolgd door selectie van die B-cellen die de hoogste affiniteit voor het betreffende antigeen hebben ontwikkeld. - Universiteit Groningen  
  • Pisciene B-cellen vertonen nauwelijks affiniteitsmaturatie (Voss et al., 1978; Arkoosh en Kaattari, 1991), hoewel somatische mutatie even frequent voorkomt als bij zoogdieren. - Universiteit Gent  
Erik van Vliet
Netherlands
Local time: 04:46
Native speaker of: Native in DutchDutch
PRO pts in category: 68
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