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  3. Biology (-tech,-chem,micro-)

conformational change

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13:01 Apr 27, 2009
English to Indonesian translations [PRO]
Science - Biology (-tech,-chem,micro-)
Additional field(s): Genetics
English term or phrase: conformational change
Definition from Biochemical Society:
Large, medium or small adjustment to the molecular shape/dynamics of a protein that may follow a change in environment or the specific recognition of another molecule.

Example sentence(s):
  • These observations indicate that heparin, in addition to causing aggregation, also induces a conformational change in tau in which reactive groups are unmasked or move closer leading to the DSS cross-linking of 72- and 83-kDa species. jbc online
  • At low pH, the hemagglutinin (HA) of influenza virus undergoes an irreversible conformational change that potentiates its essential membrane fusion function. The Rockefeller University Press
  • To develop the antibody chip for detecting the Bax conformational change, we immobilized Bax monoclonal antibody 6A7, which recognizes only a conformationally changed Bax protein on a gold surface. Elsevier Inc.
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Summary of translations provided
5perubahan konformasi
Rizqi Akbarini


  

Translations offered


45 days   confidence: Answerer confidence 5/5
perubahan konformasi


Definition from BiologyOnline:
Definisi
Perubahan bentuk yang biasanya terjadi pada struktur tersier protein akibat perubahan pH lingkungan, temperatur, kekuatan ion, ikatan dengan reseptor& ikatan dengan enzim

Example sentence(s):
  • Prion Creutzfeldt-Jakob berbahaya karena meningkatkan pelipatan protein asal ke dalam keadaan sakit, yang menyebabkan meningkatnya prion tak larut pada sel yang terjangkit. Massa protein yang salah lipat ini mengacaukan fungsi sel dan menyebabkan kematiannya. Mutasi pada gen untuk protein prion bisa menyebabkan kesalahan lipat sebagian besar regio alfa-heliks ke lembar beta yang terlipat. Perubahan konformasi ini melumpuhkan kemampuan protein mengalami pencernaan. Sekali prion ditransmisikan, protein cacat itu menyerang otak dan diproduksi di putaran umpan balik yang disokong sendiri, menyebabkan penyebaran eksponensial prion, kematian dalam beberapa bulan, meski beberapa orang diketahui hidup selama-lamanya 2 tahun. - wikipedia  
Rizqi Akbarini
United States
Local time: 18:51
Native speaker of: Indonesian
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