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  3. Biology (-tech,-chem,micro-)

nucleotide antimetabolite

Italian translation: antimetabolita nucleotidico

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:nucleotide antimetabolite
Italian translation:antimetabolita nucleotidico
Entered by: federica gagliardi

14:36 Aug 19, 2013
English to Italian translations [PRO]
Medical - Biology (-tech,-chem,micro-) / antiparassitari
English term or phrase: nucleotide antimetabolite
Un progetto UE esplora il potenziale antiparassitario di nuovi derivati delle basi azotate.

Among the project's objectives were to screen drug-like compounds in vitro and in vivo, as well as to synthesise novel ones. To this end, a library of nearly 7 000 nucleoside and nucleobase derivatives was screened and several compounds exhibited anti-parasite activity especially against T. cruzi. An alternative strategy was explored, that entailed the targeting of the deoxyuridine triphosphate nucleotidohydrolase (dUTPase) enzyme implicated in nucleotide metabolism. (...)
Although the ***nucleotide antimetabolite ***work of the project exhibited higher anti-parasite potential, information generated on the dUTPase enzyme in particular is expected to drive future research on this target.

Grazie
federica gagliardi
Italy
Local time: 15:14
antimetabolita nucleotidico
Explanation:
.
Selected response from:

Gaetano Silvestri Campagnano
Italy
Local time: 15:14
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3 KudoZ points were awarded for this answer



Summary of answers provided
4antimetabolita nucleotidico
Gaetano Silvestri Campagnano


  

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2 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
antimetabolita nucleotidico


Explanation:
.

Gaetano Silvestri Campagnano
Italy
Local time: 15:14
Specializes in field
Native speaker of: Native in ItalianItalian
PRO pts in category: 290
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