flow-over (bioreactor)

Italian translation: (bioreattore) a scorrimento superiore

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:flow-over (bioreactor)
Italian translation:(bioreattore) a scorrimento superiore
Entered by: federica gagliardi

13:04 Aug 16, 2016
English to Italian translations [PRO]
Science - Biology (-tech,-chem,micro-) / bioreattori
English term or phrase: flow-over (bioreactor)
Un progetto di ricerca UE ha ideato un bioreattore che supporta l'interazione degli epatociti con la frazione non parenchimale del fegato come le cellule stellate epatiche (HSC) e le cellule endoteliali sinusoidali del fegato (LSEC) per favorire test di tossicità in vitro.

With respect to the bioreactor itself, the consortium followed two approaches, namely an antibody-based microfluidic system and a ***flow-over bioreactor***. (...)
The flow-over stainless steel bioreactor protects hepatocytes from shear forces by maintaining stable oxygen and nutrient gradients.

Qualcuno sa dirmi come tradurlo?

Grazie
federica gagliardi
Italy
Local time: 16:08
(bioreattore) a scorrimento superiore
Explanation:
Non semplice, ma interessante. Da quanto mi sembra di capire si tratta di un tipo di bioreattore simile a quello descritto di seguito, in cui il mezzo di coltura scorre superiomente alle cellule.

Non trovo riscontri in italiano (né in itangliano :) ma direi come sopra, per evitare di essere eccessivamente prolissi. Trattandosi di mezzo di coltura, è preferibile scorrimento e non flusso IMO.

Another example of a dynamic culture system is the perfusion bioreactor. Such systems utilize a pump that allows for the medium to flow over culture surfaces. Incorporating flow into the culture conditions is used in both two-dimensional and three-dimensional cultures. For two-dimensional cultures, cells grow on an interior surface of a chamber, which has an inlet and outlet for medium to pass over the cells (Figure 17.11). The three-dimensional system is very similar, except that the medium either is pumped through the cell-containing scaffolds or is dripped on top of the scaffolds and allowed to flow through via gravity

These bioreactors are usually closed systems, allowing for the medium to be passed over the culture surfaces several times before it’s replaced with fresh medium.
Advantages to having the medium flow over the cells are realized through the effects that are brought about by having the cells exposed to controlled and directional shear, which aid in the differentiation of pluripotent and multipotent cells
http://www.sciencedirect.com/topics/page/Bioreactors

Once seeded, spheroids rest on a polycarbonate membrane with 12 µm pore size, allowing the medium to flow-through, while flow-over is maintained to avoid an excess pressure on the cells.
https://biblio.ugent.be/publication/7003105
Selected response from:

texjax DDS PhD
Local time: 11:08
Grading comment
grazie mille!
4 KudoZ points were awarded for this answer



Summary of answers provided
3(bioreattore) a scorrimento superiore
texjax DDS PhD


  

Answers


4 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
(bioreattore) a scorrimento superiore


Explanation:
Non semplice, ma interessante. Da quanto mi sembra di capire si tratta di un tipo di bioreattore simile a quello descritto di seguito, in cui il mezzo di coltura scorre superiomente alle cellule.

Non trovo riscontri in italiano (né in itangliano :) ma direi come sopra, per evitare di essere eccessivamente prolissi. Trattandosi di mezzo di coltura, è preferibile scorrimento e non flusso IMO.

Another example of a dynamic culture system is the perfusion bioreactor. Such systems utilize a pump that allows for the medium to flow over culture surfaces. Incorporating flow into the culture conditions is used in both two-dimensional and three-dimensional cultures. For two-dimensional cultures, cells grow on an interior surface of a chamber, which has an inlet and outlet for medium to pass over the cells (Figure 17.11). The three-dimensional system is very similar, except that the medium either is pumped through the cell-containing scaffolds or is dripped on top of the scaffolds and allowed to flow through via gravity

These bioreactors are usually closed systems, allowing for the medium to be passed over the culture surfaces several times before it’s replaced with fresh medium.
Advantages to having the medium flow over the cells are realized through the effects that are brought about by having the cells exposed to controlled and directional shear, which aid in the differentiation of pluripotent and multipotent cells
http://www.sciencedirect.com/topics/page/Bioreactors

Once seeded, spheroids rest on a polycarbonate membrane with 12 µm pore size, allowing the medium to flow-through, while flow-over is maintained to avoid an excess pressure on the cells.
https://biblio.ugent.be/publication/7003105

texjax DDS PhD
Local time: 11:08
Works in field
Native speaker of: Native in ItalianItalian
PRO pts in category: 102
Grading comment
grazie mille!
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