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affinity maturation

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00:56 Oct 28, 2020
English to Polish translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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Question posted on behalf of translation team:
GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
4 +1dojrzewanie powinowactwa
Frank Szmulowicz, Ph. D.


  

Translations offered


1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
dojrzewanie powinowactwa


Definition from netinbag:
Dojrzewanie powinowactwa jest odpowiedzią układu odpornościowego. Termin ten opisuje działanie pewnego rodzaju limfocytów zwanych komórkami B i ich reakcję na ekspozycję na antygen. Jest to proces zmiany i selekcji komórek.

Układ odpornościowy jest odpowiedzialny za ochronę organizmu przed obcymi antygenami. Odbywa się to poprzez tworzenie przeciwciał, które atakują i neutralizują antygeny, zanim mogą spowodować problemy. Dojrzewanie powinowactwa jest procesem, który określa rolę komórek B w odpowiedzi układu odpornościowego.

Example sentence(s):
  • Wydajne dojrzewanie powinowactwa domen zmiennych przeciwciała wymaga kooptacji mutacji kompensacyjnych w celu utrzymania stabilności termodynamicznej - pl.ovalengineering.com  
  • Co to dojrzewanie powinowactwa? (affinity maturation) Zwiększenie powinowactwa przeciwciał po kolejnym kontakcie z antygenem - quizlet  
Frank Szmulowicz, Ph. D.
United States
Local time: 12:51
Native speaker of: Native in EnglishEnglish, Native in PolishPolish
PRO pts in category: 2217

Votes in favor of/against selecting this as the best translation of the term asked
Yes  Kamila Ołtarzewska
12 hrs
  -> Dziękuję Kamilo.
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