GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW) | ||||||
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18:27 Feb 23, 2021 |
English to Polish translations [PRO] Medical - Medical: Pharmaceuticals | |||||||
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| Selected response from: Frank Szmulowicz, Ph. D. United States Local time: 08:43 | ||||||
Grading comment
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Summary of answers provided | ||||
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2 | szybkości wiązania/dysocjacji. |
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szybkości wiązania/dysocjacji. Explanation: This looks like the rate of binding/unbinding, that is, szybkości wiązania/dysocjacji. ccccccc Medicinal chemists talk a lot more about residence time and off rate than they used to. It’s become clear that (at least in some cases) a key part of a drug’s action is its kinetic behavior, specifically how quickly it leaves its binding site. You’d think that this would correlate well with its potency, but that’s not necessarily so. Binding constants are a mix of on- and off-rates, and you can get to the same number by a variety of different means. Only if you’re looking at very similar compounds with the same binding modes can you expect the correlation your intuition is telling you about, and even then you don’t always get it. https://blogs.sciencemag.org/pipeline/archives/2013/10/29/un... -------------------------------------------------- Note added at 3 hrs (2021-02-23 22:00:33 GMT) -------------------------------------------------- The binding constant is a special case of the equilibrium constant It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as: . The reaction is characterized by the on-rate constant , which have units of 1/(concentration time) and 1/time, respectively. In equilibrium, the forward binding transition should be balanced by the backward unbinding transition. |
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