on/off rate

Polish translation: szybkości wiązania/dysocjacji.

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:on/off rate
Polish translation:szybkości wiązania/dysocjacji.
Entered by: Frank Szmulowicz, Ph. D.

18:27 Feb 23, 2021
English to Polish translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: on/off rate
[DRUG] showed reversible binding to the receptor and a fast on/off rate.
Ka De
Local time: 13:43
szybkości wiązania/dysocjacji.
Explanation:
This looks like the rate of binding/unbinding, that is, szybkości wiązania/dysocjacji.

ccccccc
Medicinal chemists talk a lot more about residence time and off rate than they used to. It’s become clear that (at least in some cases) a key part of a drug’s action is its kinetic behavior, specifically how quickly it leaves its binding site. You’d think that this would correlate well with its potency, but that’s not necessarily so. Binding constants are a mix of on- and off-rates, and you can get to the same number by a variety of different means. Only if you’re looking at very similar compounds with the same binding modes can you expect the correlation your intuition is telling you about, and even then you don’t always get it.

https://blogs.sciencemag.org/pipeline/archives/2013/10/29/un...


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Note added at 3 hrs (2021-02-23 22:00:33 GMT)
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The binding constant is a special case of the equilibrium constant It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as:
.
The reaction is characterized by the on-rate constant , which have units of 1/(concentration time) and 1/time, respectively. In equilibrium, the forward binding transition should be balanced by the backward unbinding transition.
Selected response from:

Frank Szmulowicz, Ph. D.
United States
Local time: 08:43
Grading comment
2 KudoZ points were awarded for this answer



Summary of answers provided
2szybkości wiązania/dysocjacji.
Frank Szmulowicz, Ph. D.


  

Answers


3 hrs   confidence: Answerer confidence 2/5Answerer confidence 2/5
szybkości wiązania/dysocjacji.


Explanation:
This looks like the rate of binding/unbinding, that is, szybkości wiązania/dysocjacji.

ccccccc
Medicinal chemists talk a lot more about residence time and off rate than they used to. It’s become clear that (at least in some cases) a key part of a drug’s action is its kinetic behavior, specifically how quickly it leaves its binding site. You’d think that this would correlate well with its potency, but that’s not necessarily so. Binding constants are a mix of on- and off-rates, and you can get to the same number by a variety of different means. Only if you’re looking at very similar compounds with the same binding modes can you expect the correlation your intuition is telling you about, and even then you don’t always get it.

https://blogs.sciencemag.org/pipeline/archives/2013/10/29/un...


--------------------------------------------------
Note added at 3 hrs (2021-02-23 22:00:33 GMT)
--------------------------------------------------

The binding constant is a special case of the equilibrium constant It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as:
.
The reaction is characterized by the on-rate constant , which have units of 1/(concentration time) and 1/time, respectively. In equilibrium, the forward binding transition should be balanced by the backward unbinding transition.

Frank Szmulowicz, Ph. D.
United States
Local time: 08:43
Works in field
Native speaker of: Native in EnglishEnglish, Native in PolishPolish
PRO pts in category: 360
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