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  3. Medical: Pharmaceuticals

target-mediated sink effect

Polish translation: zjawisko wysokiego powinnowactwa substancji do miejsc wiążących (ang. TMDD)

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:target-mediated sink effect
Polish translation:zjawisko wysokiego powinnowactwa substancji do miejsc wiążących (ang. TMDD)
Entered by: Ewa Chojnowska

16:46 Mar 4, 2021
English to Polish translations [PRO]
Medical - Medical: Pharmaceuticals / MM
English term or phrase: target-mediated sink effect
Figures show the agent serum concentrations over time. In most patients, a dominant target-mediated sink effect was observed leading to low or no detectable serum trough levels. In contrast, patients treated with a higher dose showed constant or slightly accumulating trough level.
Ewa Chojnowska
Local time: 19:58
zjawisko wysokiego powinnowactwa substancji do miejsc wiążących (ang. TMDD)
Explanation:
This should be the same as TMDD, that is, target-mediated drug disposition. I have not found a Polish term so I provided a descriptive definition.
cccccccc
is known as target-mediated drug disposition (TMDD) or the "antigen sink effect" (Krippendorff et al., 2009;Mager, 2006;Wang et al., 2012).

https://www.researchgate.net/publication/7305753_Target-medi...
cccccccccccccccccccccccccccccccccccccccc
Target-mediated drug disposition (TMDD) is a term to describe a nonlinear pharmacokinetics (PK) phenomenon that is caused by high-affinity binding of a compound to its pharmacologic targets.
Selected response from:

Frank Szmulowicz, Ph. D.
United States
Local time: 13:58
Grading comment
Bardzo dziękuję.
4 KudoZ points were awarded for this answer



Summary of answers provided
2zjawisko wysokiego powinnowactwa substancji do miejsc wiążących (ang. TMDD)
Frank Szmulowicz, Ph. D.


Discussion entries: 1





  

Answers


1 hr   confidence: Answerer confidence 2/5Answerer confidence 2/5
zjawisko wysokiego powinnowactwa substancji do miejsc wiążących (ang. TMDD)


Explanation:
This should be the same as TMDD, that is, target-mediated drug disposition. I have not found a Polish term so I provided a descriptive definition.
cccccccc
is known as target-mediated drug disposition (TMDD) or the "antigen sink effect" (Krippendorff et al., 2009;Mager, 2006;Wang et al., 2012).

https://www.researchgate.net/publication/7305753_Target-medi...
cccccccccccccccccccccccccccccccccccccccc
Target-mediated drug disposition (TMDD) is a term to describe a nonlinear pharmacokinetics (PK) phenomenon that is caused by high-affinity binding of a compound to its pharmacologic targets.

Frank Szmulowicz, Ph. D.
United States
Local time: 13:58
Works in field
Native speaker of: Native in EnglishEnglish, Native in PolishPolish
PRO pts in category: 360
Grading comment
Bardzo dziękuję.
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