gapmer

Portuguese translation: gapmer (gap-mer)

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)

English term or phrase:	gapmer
Portuguese translation:	gapmer (gap-mer)

16:43 Jul 10, 2010

The asker opted for community grading. The question was closed on 2010-07-14 14:54:10 based on peer agreement (or, if there were too few peer comments, asker preference.)

English to Portuguese translations [PRO]
Science - Genetics

English term or phrase: gapmer

antisense compound;
"Gapmer or chimeric antisense oligomers that have a short stretch of phosphorothioate DNA (5-12 nucleotides) have been used to obtain RNase-H mediated cleavage of target RNAs, while reducing the number of phosphorothioate linkages"

carolcorrea_uff

gapmer (gap-mer)

Explanation:
Entendo que não se traduz.

Eficaz de la inhibición del VIH-1 de expresión LNA modificados ...
- [ Traduzir esta página ]
En este sentido, la prueba de ADN y LNA (gap-mer) oligos antisentido, ..... A la luz de nuestros datos in vitro, esta inducción es más probable resultado de ...
viaclinica.com/article.php?pmc_id=1866241 - Em cache

Selected response from:

Salvador Scofano and Gry Midttun
Norway
Local time: 21:52

Grading comment

Obrigada!
4 KudoZ points were awarded for this answer

Summary of answers provided

4 +2

gapmer (gap-mer)

Salvador Scofano and Gry Midttun

Summary of reference entries provided

liz askew

Answers

8 mins confidence:

peer agreement (net): +2

gapmer (gap-mer)

Salvador Scofano and Gry Midttun
Norway
Local time: 21:52
Native speaker of:

Norwegian,

Portuguese
PRO pts in category: 40

Grading comment

Obrigada!

Reference comments

1 hr

Reference

Reference information:
Hello there
I have found absolutely nothing in Portuguese, only some explanations in English of what "gapmers" are:)

http://ukpmc.ac.uk/articles/PMC37256
Modifications to this basic approach have included ‘gapmer oligonucleotides’ (30), where windows or ‘gaps’ of DNA are inserted into an otherwise normal or modified RNA oligonucleotide.
30. Monia B.P., Lesnik,E.A., Gonzalez,C., Lima,W.F., McGee,D., Guinosso,C.J., Kawasaki,A.M., Cook,P.D. and Freier,S.M. (1993) Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as anti-sense inhibitors of gene expression. J. Biol. Chem., 268, 14514–14522. [PubMed]
Identifying ribozyme-accessible sites using NUH triplet-targeting ...
Modifications to this basic approach have included 'gapmer oligonucleotides' (30), where windows or 'gaps' of DNA are inserted into an otherwise normal or ...
nar.oxfordjournals.org/cgi/content/full/29/9/1906

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Note added at 1 hr (2010-07-10 18:10:52 GMT)
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p.s.
I have only found "quiméricos" in Portuguese, for "chimeric".

http://www.google.co.uk/search?hl=en&as_q=oligonucleotidos q...

liz askew
United Kingdom
Native speaker of:

English
PRO pts in category: 8

Note to reference poster

Asker: Thanks.

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gapmer

Portuguese translation: gapmer (gap-mer)

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