This site uses cookies. Some of these cookies are essential to the operation of the site, while others help to improve your experience by providing insights into how the site is being used. For more information, please see the ProZ.com privacy policy.
Cookie settings
  1. KudoZ™ Top
  2. English to Russian
  3. Biology (-tech,-chem,micro-)

developability score

Russian translation: индекс реализуемости

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:developability score
Russian translation:индекс реализуемости
Entered by: Wolfskin

10:41 Nov 14, 2019
English to Russian translations [PRO]
Law/Patents - Biology (-tech,-chem,micro-) / Мультиспецифические антитела
English term or phrase: developability score
A “developability score” also known as a “developability profile”, refers to an index that may be assigned to the inventive CD3 binding domains and/or antibodies comprising them upon assessing developability as described herein and in, e.g., WO 2014/179363

В приведенной ссылке термин так поясняют:
In accordance with the disclosed methods, "developability" refers to the extent to which one or more polypeptides in a plurality of polypeptides possess desirable characteristics, such as, e.g.: desirable expression, for example, in mammalian cells; solubility; viscosity; aggregation; chemical and/or physical stability; desirable "shelf-life"; melting temperature; pharmacokinetic profiles; circulation half-life; and clearance characteristics. Such characteristics may serve as indicia, independently, as combinations of sub-sets of such indicia, or in totality, for the likelihood that such one or more polypeptides may be successfully developed as a therapeutic candidate, and ultimately an approved drug.

Показатель разработанности?
Спасибо.
Wolfskin
Local time: 04:44
индекс реализуемости
Explanation:
Выдержка из ссылки: These failures have prompted the development of predictive in vitro assays that screen for desirable biophysical properties in the early discovery phases (“developability”) to anticipate the clinical success of antibodies.
Т.е, речь идет о принципиальной достижимости, разрабатываемости, а не разработанности
Selected response from:

Pavel Altukhov
Local time: 04:44
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3индекс реализуемости
Pavel Altukhov


  

Answers


12 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
индекс реализуемости


Explanation:
Выдержка из ссылки: These failures have prompted the development of predictive in vitro assays that screen for desirable biophysical properties in the early discovery phases (“developability”) to anticipate the clinical success of antibodies.
Т.е, речь идет о принципиальной достижимости, разрабатываемости, а не разработанности


    Reference: http://www-vendruscolo.ch.cam.ac.uk/wolf-perez2019mabs.pdf
Pavel Altukhov
Local time: 04:44
Works in field
Native speaker of: Russian
PRO pts in category: 28
Notes to answerer
Asker: Спасибо за ответ

Login to enter a peer comment (or grade)



Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.

Return to KudoZ list

KudoZ™ translation help

The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

See also:
ProZ.com term search
Search millions of term translations
Close search
Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search