This site uses cookies. Some of these cookies are essential to the operation of the site, while others help to improve your experience by providing insights into how the site is being used. For more information, please see the ProZ.com privacy policy.
Cookie settings
  1. KudoZ™ Top
  2. English to Russian
  3. Medical: Pharmaceuticals

automated parallel patch clamp system

Russian translation: автоматизированная система параллельной/одновременной локальной фиксации потенциала

09:20 Nov 25, 2019
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: automated parallel patch clamp system
Following the reduction of blood pressure, heart rate increased from 4 through 19 h post-dose (as much as 67%), which resulted in PR and QT interval decreases from 1 through 7 h post-dose and from 4 through 19 h post-dose, respectively.
No AG10-related effects were noted for qualitative ECG, QRS duration, QTc interval, or body temperature.
The no observed effect level (NOEL) was 200 mg/kg dosed once.
The in vitro effects of AG10 on the hERG potassium channel current expressed in mammalian cells were evaluated using an *automated parallel patch clamp system*.
AG10 had an IC50 >100 μM.
The positive control (E-4031) confirmed the sensitivity of the test system to hERG inhibition.
In summary, the cardiovascular safety of AG10 was assessed in vitro and in vivo.
Maxim Polukhin
Local time: 22:54
Russian translation:автоматизированная система параллельной/одновременной локальной фиксации потенциала
Explanation:
patch clamp - метод локальной фиксации потенциала [мембраны клетки]
automated parallel patch clamp system - вероятно имеется в виду устройство PatchXpress® 7000A Automated Parallel Patch Clamp System, которое можно назвать автоматизированной системой параллельной/одновременной локальной фиксации потенциала

Хотя если честно, что в оригинале, что в таком варианте перевода, из названия совершенно непонятно, что система способна измерять локальный мембранный потенциал одновременно в 16 различных образцах https://www.moleculardevices.com/en/assets/app-note/dd/cns/p...

Selected response from:

Igor Andreev
Local time: 22:54
Grading comment
Спасибо!
4 KudoZ points were awarded for this answer



Summary of answers provided
3автоматизированная система параллельной/одновременной локальной фиксации потенциала
Igor Andreev


  

Answers


5 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
автоматизированная система параллельной/одновременной локальной фиксации потенциала


Explanation:
patch clamp - метод локальной фиксации потенциала [мембраны клетки]
automated parallel patch clamp system - вероятно имеется в виду устройство PatchXpress® 7000A Automated Parallel Patch Clamp System, которое можно назвать автоматизированной системой параллельной/одновременной локальной фиксации потенциала

Хотя если честно, что в оригинале, что в таком варианте перевода, из названия совершенно непонятно, что система способна измерять локальный мембранный потенциал одновременно в 16 различных образцах https://www.moleculardevices.com/en/assets/app-note/dd/cns/p...



Igor Andreev
Local time: 22:54
Native speaker of: Native in RussianRussian
PRO pts in category: 625
Grading comment
Спасибо!
Login to enter a peer comment (or grade)



Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.

Return to KudoZ list

KudoZ™ translation help

The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

See also:
ProZ.com term search
Search millions of term translations
Close search
Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search