14:54 May 2, 2015
Postoji termin early withdrawal i prevodi se kao prevremeno povlačenje i znači to što ste naveli u vašem odgovoru. Ono što tražim je nešto drugo: Adaptive crossover trial designs, giving patients the option to opt out or ‘escape’ the assigned treatment, can improve outcome efficiency and statistical significance. Increasingly designed to investigate new treatments for rare diseases, crossover trials involve two or more treatments administered in a set order to each patient and for set periods throughout the study. Patient 1 will receive treatment A followed by treatment B, whilst Patient 2 will receive treatment B followed by treatment A for the same period. Crossover trials therefore minimize patient exposure to ineffective treatments and increase efficiency since patients act as their own control and response to treatment is rapidly measured. Pacijenti koji ispune kriterijum "early escape" ne napuštaju studiju, nego umesto studijskog, počinju da primaju neki drugi lek, koji je standardna terapija za tu bolest, ali pod nadzorom studijskog lekara. |