Target Potency Vaccine

Spanish translation: vacuna de potencia objetivo

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:Target Potency Vaccine
Spanish translation:vacuna de potencia objetivo
Entered by: Eloisa Anchezar

18:35 Feb 15, 2021
English to Spanish translations [PRO]
Medical - Other / Validation of the in vitro ELISA potency test
English term or phrase: Target Potency Vaccine
hace referencia al objetivo de potencia de la vacuna??

Reagents/Biologicals to be used as samples in the Optimization and Verification Studies
Material Name
Section of Protocol for use
Identification/Description
Subpotent Vaccine (0.8)
Accuracy/Precision Discrimination
MR 49004-300 (300FTU)
MR diluted to an RP target of approximately 0.8.
Potent Vaccine (120%)
Accuracy/Precision Discrimination
Final product vaccine diluted to approximately +20% of efficacy (approximately 360FTU)
Target Potency Vaccine (Final Product)

Note: formulation matrix for all vaccine samples tested are representative of the commercial vaccine.

gracias!!
Eloisa Anchezar
Argentina
Local time: 13:06
vacuna de potencia objetivo
Explanation:
Potencia y eficacia son conceptos distintos en inmunología. Potency se traduce como potencia.

https://vichsec.org/en/outreach-forum/index.php?option=com_a...
"Efficacy vs Potency
Efficacy (immunogenicity):
-Direct effect of a treatment on an individual subject
-Pivotal host animal vaccination-challenge study
Potency:
-Serial or batch measure
-Direct or indirect"

https://pubmed.ncbi.nlm.nih.gov/12782051/
"Because of the complexity of pathogenic processes and associated immune responses, potency tests may not always directly predict the effectiveness of a vaccine. Thus, vaccines that pass control potency testing may not always provide adequate efficacy."
" Also, the effects of the dose and duration of antigen exposure as well as the nature of antigen presentation and generation of extrinsic cytokines could be characterised and correlated to vaccine potency as additional indicators of vaccine efficacy. "
Selected response from:

Daniel Delgado
Argentina
Local time: 09:06
Grading comment
Gracias!!!
4 KudoZ points were awarded for this answer



Summary of answers provided
4vacuna de potencia objetivo
Daniel Delgado
3vacuna de eficacia objetivo
Marcelo Viera


  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5
target potency vaccine
vacuna de eficacia objetivo


Explanation:

Potency requirements

The eighth report of the WHO Expert Committee on Rabies suggested that inactivated veterinary vaccines with a potency of less than 1.0 IU per dose, as measured by the NIH test, should not be licensed or released unless an adequately designed experiment has demonstrated a duration of immunity of at least one year in the species for which the vaccine is to be used.

The potency of live and inactivated vaccines should be ascertained at intervals after they have been distributed. Inactivated vaccine, even in liquid form, and lyophilized modified live-virus vaccines are relatively stable when stored under proper conditions. To verify that storage conditions are adequate, it is recommended that samples from the field that are approaching their expiry date be tested using the methods applied to newly manufactured products.


    https://www.who.int/rabies/vaccines/potency_requirements/en/
Marcelo Viera
Uruguay
Local time: 09:06
Native speaker of: Spanish
PRO pts in category: 12
Notes to answerer
Asker: muchas gracias Marcelo por toda tu ayuda!

Login to enter a peer comment (or grade)

2 days 17 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
target potency vaccine
vacuna de potencia objetivo


Explanation:
Potencia y eficacia son conceptos distintos en inmunología. Potency se traduce como potencia.

https://vichsec.org/en/outreach-forum/index.php?option=com_a...
"Efficacy vs Potency
Efficacy (immunogenicity):
-Direct effect of a treatment on an individual subject
-Pivotal host animal vaccination-challenge study
Potency:
-Serial or batch measure
-Direct or indirect"

https://pubmed.ncbi.nlm.nih.gov/12782051/
"Because of the complexity of pathogenic processes and associated immune responses, potency tests may not always directly predict the effectiveness of a vaccine. Thus, vaccines that pass control potency testing may not always provide adequate efficacy."
" Also, the effects of the dose and duration of antigen exposure as well as the nature of antigen presentation and generation of extrinsic cytokines could be characterised and correlated to vaccine potency as additional indicators of vaccine efficacy. "



    https://www.linguee.com/english-spanish/search?source=auto&query=potency
Daniel Delgado
Argentina
Local time: 09:06
Native speaker of: Spanish
PRO pts in category: 136
Grading comment
Gracias!!!
Login to enter a peer comment (or grade)



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