SIR2 slows down gene activity

English translation: some explanation

18:44 Oct 7, 2004
English language (monolingual) [PRO]
Medical - Genetics
English term or phrase: SIR2 slows down gene activity
This may explain why calorie restriction increases life span, becouse SIR2 slows down gene activity when a cell is being starved.

How gene SIR2 can slow down gene activity? Is there a mistake in the text? Perhaps it should be: gene SIR2 slows down other genes activity.
melon
Selected answer:some explanation
Explanation:
I agree with the previous posting in that it is not a mistake, but I thought I'd just provide a little bit of explanation as you sound like you're confused about what they are saying. One of the things that Sir2 does is to 'silence' genes. Don't get confused here though, it is not the gene for Sir2 that does this, but the product of that gene (a protein). In this respect your confusion is accurate, one gene cannot slow down the activity of another. But, when Sir2 protein has been produced using the information from its gene, one of its jobs is to stop the information from many other genes being used to make their corresponding proteins. In other words, Sir2 can 'slow down' the 'activity' of other genes by 'silencing' them, or stopping them being copied to produce proteins.

I hope this helps a bit. Sir2 is a fairly hot topic at the moment!

All the best, Iain
Selected response from:

n/a (X)
Grading comment
That was a great help. Thank you very much!!!!
4 KudoZ points were awarded for this answer



SUMMARY OF ALL EXPLANATIONS PROVIDED
5 +3some explanation
n/a (X)
5it is correct
Clauwolf


  

Answers


17 mins   confidence: Answerer confidence 5/5
sir2 slows down gene activity
it is correct


Explanation:
:)

Clauwolf
Local time: 01:09
Native speaker of: Native in PortuguesePortuguese
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48 mins   confidence: Answerer confidence 5/5 peer agreement (net): +3
sir2 slows down gene activity
some explanation


Explanation:
I agree with the previous posting in that it is not a mistake, but I thought I'd just provide a little bit of explanation as you sound like you're confused about what they are saying. One of the things that Sir2 does is to 'silence' genes. Don't get confused here though, it is not the gene for Sir2 that does this, but the product of that gene (a protein). In this respect your confusion is accurate, one gene cannot slow down the activity of another. But, when Sir2 protein has been produced using the information from its gene, one of its jobs is to stop the information from many other genes being used to make their corresponding proteins. In other words, Sir2 can 'slow down' the 'activity' of other genes by 'silencing' them, or stopping them being copied to produce proteins.

I hope this helps a bit. Sir2 is a fairly hot topic at the moment!

All the best, Iain

n/a (X)
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 4
Grading comment
That was a great help. Thank you very much!!!!

Peer comments on this answer (and responses from the answerer)
agree  Veronica Prpic Uhing: Nice explanation Iain
1 hr
  -> Thank you :-)

agree  Jörgen Slet
2 hrs
  -> Thanks Jörgen

agree  Nizamettin Yigit
2 hrs
  -> Thanks Nizamettin
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