water loaded rats

01:40 Mar 22, 2020
English language (monolingual) [PRO]
Medical - Medical (general)
English term or phrase: water loaded rats
in water-loaded, alcohol-anesthetized rats.
Medical usage in in vivo experiments
In in vivo experiments, the compound antagonized the antidiuretic action of exogenous vasopressin in water-loaded, alcohol-anesthetized rats.
Stella Nör


SUMMARY OF ALL EXPLANATIONS PROVIDED
4 +1rats that have been injected with water to make the animals well hydrated
Kiet Bach
5rats are filled with water via a tube into their stomach
Lydia De Jorge
4 +1rats who have lots of water in their bodies
Michael Barnett


Discussion entries: 2





  

Answers


3 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
rats that have been injected with water to make the animals well hydrated


Explanation:
water is injected either intragastrically or intraperitoneally.

https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/jphys...

Kiet Bach
United States
Local time: 02:58
Specializes in field
Native speaker of: Native in ChineseChinese
PRO pts in category: 12

Peer comments on this answer (and responses from the answerer)
neutral  Tony M: Indeed, possibly over-hydrated! BUT the source text gives us no clues as to HOW the water got there, so we should avoid over-interpretation.
3 hrs

agree  Tina Vonhof (X): Agree with Tony: the use of 'water-loaded' instead of 'hydrated' seems to indicate more than just hydrated.
11 hrs

agree  Polangmar: The method used for over-hydration and anaesthesia was to administer a 12% ethanol solution by stomach tube. (...) Variation... Instead of the initial intragastric loading, the fluid was given intravenously through a cannula inserted 24 hr previously.
14 hrs

disagree  Michael Barnett: Stick to translation. You have no idea how the water got there.
22 hrs
  -> to load: to put something into or onto

agree  Maitê Dietze
1 day 14 hrs

disagree  Daryo: if there is an "injection" in the ST it's doing a damn good job at hiding ... the point is in the rat's body being saturated with water, how that happened is neither here nor there.
1 day 14 hrs
  -> "body saturated with water"? One more drop and the rat blows up?
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16 hrs   confidence: Answerer confidence 5/5
rats are filled with water via a tube into their stomach


Explanation:
https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/jphys...

METHODS
Mice. The experiments were performed on male mice, 5 weeks old, from the strains CBA/FaCam, A/Cam, Peru and RAP.
Water-loading. Each mouse was induced to empty its bladder by tickling and ifnecessary squeezing the bladder. The mouse was then weighed and lightly anaesthetized with ether. Under anaesthesia a fine polyethylene tube was passed into the stomach and a volume of I ml./16 g body wt. of water delivered from a syringe over a period of about 15 sec. The mouse was unconscious for 10-20 sec, during intubation and the initial administration of water.Afterwater-loadingthemiceappearedtobehavenormallyinabout95% ofthecases. Those mice that were obviously affected by the water-loading procedure were not included in the experimental results.

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Note added at 16 hrs (2020-03-22 18:12:41 GMT)
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Under anaesthesia a fine polyethylene tube was passed into the stomach

Lydia De Jorge
United States
Local time: 04:58
Works in field
Native speaker of: Native in SpanishSpanish, Native in EnglishEnglish

Peer comments on this answer (and responses from the answerer)
neutral  Polangmar: In fact, we don't know the method used in the asker's case (see my comment under the first answer).
57 mins
  -> I am merely showing that water-loading is, which is what the asker is asking.

disagree  Michael Barnett: Stick to translation.//Good point! :-)
9 hrs
  -> Translation? MONOLINGUAL.

neutral  Tony M: the source text gives us no clues as to HOW the water got there, so we should avoid over-interpretation.
11 hrs
  -> Yes and no. The source indicates a medical experiment (with rats). The asker wants to know what water loaded means. Water-loaded is a specific term (see my explanation above).

agree  Maitê Dietze
1 day 38 mins
  -> thank you! Cheers!
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1 day 1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
rats who have lots of water in their bodies


Explanation:
Water-loaded just means the rats have lots of water in their bodies. They may have too much water, but that is more implied than explicitly stated. It says nothing about how the water got there. To suggest that the water was administered by intravenous injection or by gastric cannula is pure imagination as it appears nowhere in the source text. In fact, I suspect that the rats became loaded with water by giving them vasopressin, which inhibits the excretion of water by the kidneys, causing the rats to become "loaded".

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Note added at 1 day 1 hr (2020-03-23 03:38:37 GMT)
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BTW, my confidence level is 5 not 4.

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Note added at 1 day 2 hrs (2020-03-23 03:47:19 GMT)
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To be more precise, giving them vasopressin after letting them drink to satisfaction.

Michael Barnett
Local time: 05:58
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 138

Peer comments on this answer (and responses from the answerer)
agree  Daryo
15 hrs
  -> Thanks Daryo

disagree  Kiet Bach: To load: to put something into or onto. The water is loaded into the rats, not the rats drink water themselves. Exactly, bullets are loaded into the gun (by somebody). A gun cannot load itself.
16 hrs
  -> The state of being loaded makes no assumption on how the subject came to be loaded. We often say in English that a person is loaded with money (rich) or loaded with alcohol (drunk). A loaded gun has bullets. How the bullets got there is not the issue.

agree  Yvonne Gallagher: Yep, ST doeasn't tell us here HOW they have become water-loaded
10 days
  -> Thank you Yvonne!
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