cholestase

English translation: 2-3 fold increase in cholestasis markers/enzymes

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
French term or phrase:cholestase à 2 à 3 fois la normale
English translation:2-3 fold increase in cholestasis markers/enzymes
Entered by: Anne Schulz

17:37 Feb 10, 2021
French to English translations [PRO]
Medical - Medical (general)
French term or phrase: cholestase
This is a case report on a patient with yellow urticaria as well as lupus.

"la patiente consulte pour un ictère cutanéomuqueux cholestatique avec à la biologie une cytolyse et une cholestase à respectivement 16 et 15 fois la normale associées à une hyperbilirubinémie à prédominance conjuguée."

A bit later it says:

"Un Overlap syndrome était retenu devant une cytolyse > 5 fois la normale et des anticorps anti-muscle lisse positifs à un titre > 1/80 soit un score révisé d’hépatite auto-immune à 16 associés à une cirrhose biliaire primitive diagnostiquée devant une cholestase > 5 fois la normale et des anticorps anti-GP210 positifs"

And:

"L’évolution était favorable avec régression de l’ictère, disparition totale de la cytolyse mais persistance d’une cholestase à 2 à 3 fois la normale."

This is puzzling me because it seems to be referring to a test that indicates "cholestasis" because as far as I'm aware, you can't have cholestasis "2 to 3 times the normal value". The language used is similar for the cytolysis mentioned in the text but at least for this I assumed that this was talking about aminotranferases levels when talking about values being increased.

Is there a test that indicates cholestasis?
Emily Gilby
United Kingdom
Local time: 09:07
cholestasis markers
Explanation:
(or "cholestasis enzymes", as mentioned in Brent's reference)

These are e.g. direct bilirubin, alkaline phosphatase, GGT. Bile acids may indicate cholestasis as well, but are not often used in clinical routine.

Selected response from:

Anne Schulz
Germany
Local time: 10:07
Grading comment
Thank you!
4 KudoZ points were awarded for this answer



Summary of answers provided
4serum bile acids
liz askew
4bilirubin buildup
Barbara Schmidt, M.A. (X)
3cholestasis
Brent Sørensen
3cholestasis markers
Anne Schulz


Discussion entries: 6





  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5
cholestasis


Explanation:




The hepatic biology showed a cholestasis (eight times the normal value) and a cytolysis (three times the normal value) (Table 1) with negative antibodies anti smooth muscle, anti LKM1 and anti-mitochondrial antibodies

https://oatext.com/tumor-syndrome-hepatic-and-hematological-...

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Note added at 1 hr (2021-02-10 19:17:43 GMT)
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The diagnosis is supposed based on the increase in transaminases, bilirubin and cholestasis enzymes levels [ cholinesterase?] and is confirmed by liver biopsy findings.

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&c...

Brent Sørensen
Germany
Local time: 10:07
Specializes in field
Native speaker of: Native in EnglishEnglish
Notes to answerer
Asker: I appreciate you looking into this Brent but judging by the quality of the English used in the article you reference, I'm not convinced by this I'm afraid

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19 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
serum bile acids


Explanation:

Intrahepatic cholestasis of pregnancy - NCBI - NIHwww.ncbi.nlm.nih.gov › pmc › articles › PMC2678574
by V Geenes · ‎2009 · ‎Cited by 550 · ‎Related articles
7 May 2009 — Clinical jaundice is rare, affecting approximately 10%-15% of ... Bile acids have been repeatedly implicated in the etiology of the fetal ... of elevations in serum bile acids as high as 100 times the upper limit of normal[73,77].

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Note added at 19 hrs (2021-02-11 12:59:22 GMT)
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A distinctive pattern of serum bile acid and bilirubin ... - PubMedpubmed.ncbi.nlm.nih.gov › ...
by JA Summerfield · ‎1981 · ‎Cited by 24 · ‎Related articles
The pattern of serial serum bile acid and bilirubin concentrations in 3 patients with benign recurrent intrahepatic cholestasis (BRIC) was compared with those ...

liz askew
United Kingdom
Local time: 09:07
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 3189
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1 day 14 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
bilirubin buildup


Explanation:
What is cholestasis?

Cholestasis is a liver disease. It occurs when the flow of bile from your liver is reduced or blocked. Bile is fluid produced by your liver that aids in the digestion of food, especially fats. When bile flow is altered, it can lead to a buildup of bilirubin. Bilirubin is a pigment produced by your liver and excreted from your body via bile.

There are two types of cholestasis: intrahepatic cholestasis and extrahepatic cholestasis.

https://www.healthline.com/health/cholestasis?c=106130655018...


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Note added at 1 Tag 14 Stunden (2021-02-12 08:31:25 GMT)
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https://www.verywellhealth.com/bilirubin-definition-and-desc...

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Note added at 1 Tag 14 Stunden (2021-02-12 08:32:21 GMT)
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or:
elevated bilirubin
etc

Barbara Schmidt, M.A. (X)
Germany
Local time: 10:07
Specializes in field
Native speaker of: German
PRO pts in category: 12
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1 day 16 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
cholestasis markers


Explanation:
(or "cholestasis enzymes", as mentioned in Brent's reference)

These are e.g. direct bilirubin, alkaline phosphatase, GGT. Bile acids may indicate cholestasis as well, but are not often used in clinical routine.



Anne Schulz
Germany
Local time: 10:07
Specializes in field
Native speaker of: German
PRO pts in category: 237
Grading comment
Thank you!
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