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  3. Medical: Pharmaceuticals

schonender [Wirkungseintritt]

English translation: gradual [onset of action]

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
German term or phrase:schonender [Wirkungseintritt]
English translation:gradual [onset of action]
Entered by: Lirka

14:18 Jun 18, 2012
German to English translations [PRO]
Medical - Medical: Pharmaceuticals
German term or phrase: schonender [Wirkungseintritt]
SPC (cholinesterase inhibitor):

"[Drug name] retard besitzt cholinerge Eigenschaften; es gehört zu den Hemmstoffen der Cholinesterasen. Unter diesen Substanzen zeichnet es sich durch gute Verträglichkeit, schonenden Wirkungseintritt, gleichmäßigen Wirkungsverlauf, lange Wirkungsdauer und allmähliches Abklingen der Wirkung aus. "

I am trying to find a suitable word for "schonend". I am entertaining the word 'gradual" but I don't want to say something that may be wrong ( I do not know if this drug has a slow or rapid onset of action).

"gradual onset of action"??

Thanks!
Lirka
Austria
Local time: 03:53
gentle [onset of action]
Explanation:
"Gentle onset of action" might possibly work here...

"If treatment is required shortly after this period, agents with a slow and gentle onset of action appear to be preferable..."

www.ncbi.nlm.nih.gov/pubmed/10551436

"Ativan is another member of that family. The only drug around which is NOT of this family, but relaxing without sleepiness, is Buspirone, though it has a gentle onset of action, and takes a couple of weeks to show its full effect."

http://www.health24.com/experts/archive/default.asp?postid=7...

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Note added at 17 mins (2012-06-18 14:35:30 GMT)
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That said, my spontaneous idea would also have been "gradual".
Selected response from:

Colin Rowe
Germany
Local time: 03:53
Grading comment
I am awarding point, though I went with "gradual" because this is what it means ( slow as opposed to fast). I wanted to stay as 'medical'/standard as possible, although I realize that the DE original wasn't that strict :) Thanks!
3 KudoZ points were awarded for this answer



Summary of answers provided
3 +5gentle [onset of action]
Colin Rowe
4smooth onset of (drug) action
uyuni
4low-grade effect
Gabriella Bertelmann
3gentle onset of effect
Carmen Lawrence
3gradual and mild onset of action
barbarameyer
3 -1kicking in gradually
Michael Martin, MA


Discussion entries: 2





  

Answers


16 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +5
gentle [onset of action]


Explanation:
"Gentle onset of action" might possibly work here...

"If treatment is required shortly after this period, agents with a slow and gentle onset of action appear to be preferable..."

www.ncbi.nlm.nih.gov/pubmed/10551436

"Ativan is another member of that family. The only drug around which is NOT of this family, but relaxing without sleepiness, is Buspirone, though it has a gentle onset of action, and takes a couple of weeks to show its full effect."

http://www.health24.com/experts/archive/default.asp?postid=7...

--------------------------------------------------
Note added at 17 mins (2012-06-18 14:35:30 GMT)
--------------------------------------------------

That said, my spontaneous idea would also have been "gradual".

Colin Rowe
Germany
Local time: 03:53
Works in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 34
Grading comment
I am awarding point, though I went with "gradual" because this is what it means ( slow as opposed to fast). I wanted to stay as 'medical'/standard as possible, although I realize that the DE original wasn't that strict :) Thanks!
Notes to answerer
Asker: "Gentle" is a safe bet, rather vague, in line with the original :) But the scientific meaning is probably gradual, even slow.


Peer comments on this answer (and responses from the answerer)
agree  Lis Liesicke: would use gradual though as "gradual onset of action"+medication (or drugs) gets far more hits than "gentle onset of action"+medication
4 mins
agree  jccantrell: But, gentle is good too. I have seen aspirin advertised as "gentle on the stomach."
39 mins
agree  philgoddard
2 hrs
agree  Harald Moelzer (medical-translator): suits the context perfectly IMO
16 hrs
agree  Ramey Rieger (X): Hi guy!
20 hrs
  -> Hello again!
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32 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
smooth onset of (drug) action


Explanation:
Es gibt zwar nur einen raschen oder aber verzögerten Wirkugseintritt; der der Arzneimittelhersteller letzteren aber offensichtlich (und wissenschaftlich kaum definiert/operationalisiert) unbedingt als *schonend* bezeichnen möchte würde ich die o.g. Formulierung wählen, die dem doch relativ nahe kommt, auch wenn es sicher keine 1:1-Übersetzung ist, zumal *schonend* keine Kategorie ist, die im engeren Sinne*rasch* oder *verzögert* abbildet...

when standard stimulant tablets or SR preparations "kick in," but this is a rare report from people treated with Adderall due to the slow, *smooth onset of action*.
http://www.addresources.org/?q=node/250

Propofol has a rapid and *smooth onset of action* and is as easy to titrate in children as in adults. Propofol can be excellently controlled.
http://www.anestesiarianimazione.com/2003/05e.asp

Carbachol has a *smooth onset of action* and relatively few side effects.
http://www.iovs.org/content/6/5/local/back-matter.pdf

...candesartan cilexetil, 8–16 mg once daily, is an effective and well- tolerated antihypertensive treatment, which has a *smooth onset of action* and...
http://informahealthcare.com/doi/abs/10.1080/080370500439317

It has a *smooth onset of action* and wears off 3 hours after it's removed. Concerta usually lasts 12 hours.
http://www.askdrjones.com/page/6/?p=vuziexuio

Data suggest that the lack of reflex sympathetic activation in response to the blood pressure-lowering effect of nisoldipine CC is due to the *smooth onset of action* ...
http://www.ncbi.nlm.nih.gov/pubmed/10344070

The *smooth onset of action* and lack of anaphylactoid membrane reactions were the main reasons...
http://www.thelancet.com/journals/lancet/article/PIIS0140-67...

The desirable characteristics of outpatient anesthetic agents include a rapid and *smooth onset of action*, intraoperative amnesia and analgesia, and...
http://www.mdconsult.com/books/page.do?eid=4-u1.0-B0-7216-72...



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Note added at 41 mins (2012-06-18 15:00:12 GMT)
--------------------------------------------------

Meines Erachtens dürfte hier letztlich ein Wirkungseintritt *without noticeable adverse effects/side effects* gemeint sein. Allerdings wäre das sicherlich nicht sonderlich idiomatisch...

uyuni
Local time: 03:53
Specializes in field
Native speaker of: Native in GermanGerman
PRO pts in category: 80
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1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5
gentle onset of effect


Explanation:
you might say gradual, but that is not a given; in any case it does not alarm the organism, as it were.

Carmen Lawrence
Greece
Local time: 04:53
Works in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 8
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2 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): -1
kicking in gradually


Explanation:
has the advantage of kicking in gradually/being gentle in its action

Those suggestions may have the disadvantage of being to colloquial for the target audience

Michael Martin, MA
United States
Local time: 21:53
Native speaker of: Native in GermanGerman, Native in EnglishEnglish
PRO pts in category: 32

Peer comments on this answer (and responses from the answerer)
disagree  philgoddard: As you say, inappropriate tone.
34 mins
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5 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
schonender Wirkungseintritt
gradual and mild onset of action


Explanation:
schonend = gradual and mild

barbarameyer
Native speaker of: Native in GermanGerman, Native in EnglishEnglish
PRO pts in category: 20
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9 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
low-grade effect


Explanation:
an option

Gabriella Bertelmann
Local time: 03:53
Works in field
Native speaker of: Native in EnglishEnglish, Native in GermanGerman
PRO pts in category: 8
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