resistenzstabil
English translation: no genotypic resistance//no drug resistance
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| 14:50 Aug 14, 2012 |
| German to English translations [PRO] Medical - Medical: Pharmaceuticals | |||||||
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|  Selected response from: Lirka Austria Local time: 23:13 | ||||||
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Answers
24 mins confidence: 
stably resistant Explanation: sustained resistance rather than sporadic or short-term resistance Reference: http://www.ncbi.nlm.nih.gov/pubmed |
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29 mins confidence:
no genotypic resistance//no drug resistance Explanation: http://www.eurekalert.org/pub_releases/2011-04/w-hbv042711.p... It means that hep B strains are not resistant to these analogues (nucleoside analogs tend to be associated with relatively high incidence of resistance) |
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1 hr confidence:
with to date the lowest rate of resistance/no resistance Explanation: .. can be successfully treated with potent nucleoside analogues with to date the lowest rate of resistance/with no resistance http://www.ccjm.org/content/76/Suppl_3/S14.long The goal of antiviral therapy for chronic hepatitis B (HBV) with oral nucleoside or nucleotide analogues is to ensure sustained suppression of HBV virologic activity as measured by quantitation of HBV DNA and ultimately, to prevent cirrhosis, hepatic failure, and hepatocellular cancer[1]. Unfortunately, prolonged therapy with these agents can result in the emergence of antiviral resistance. The development of resistance depends on a number of variables: pre-treatment HBV DNA levels, rapidity of viral suppression (often correlated with potency of agent), degree of genetic barrier to resistance of agent (threshold probability the virus will mutate under selective pressure from the drug), duration of treatment, and prior exposure to oral antiviral therapy[2]. http://depts.washington.edu/hepstudy/hepB/mgmt/treatment/dis... http://www.emedicinehealth.com/hepatitis_b_treatment/page5_e... |
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2 hrs confidence: peer agreement (net): -1
peer agreement (net): -1(nucleoside analogues) not susceptible to resistance Explanation: My take... Apologies, no time to provide accurate URLs - off to Scotland within hours... ;-)) |
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