antriebssteigernde Wirkung

English translation: activating effect/(properties)

12:59 Sep 15, 2015
German to English translations [PRO]
Medical - Medical: Pharmaceuticals / antidepressants
German term or phrase: antriebssteigernde Wirkung
This appears in a pharmacotherapy handbook:

"Klinisch bewährt hat sich auch die Kombination von Venlafaxin mit Mirtazapin, wie auch die STAR*D-Studie bestätigt. Hierbei wird die antriebssteigernde Wirkung von Venlafaxin mit der gleichzeitigen Förderung des Schlafes durch Mirtazapin vereint."
Robert McCulloch
Local time: 21:57
English translation:activating effect/(properties)
Explanation:
In some patients, antidepressants can cause an *activating effect*. This means that a person who before was so depressed that they could hardly get out of bed now has more energy, but is still depressed and irritable.
http://lifepsychiatrist.com/inside-antidepressant-black-box/

This led to the belief that antidepressants may have an *activating effect* that allows patients to follow through on their suicidal impulses.
https://books.google.de/books?id=_8N-nc-GsmgC&pg=PA7&lpg=PA7...

SSRIs may have an initial *activating effect* that can intensify some symptoms of anxiety.
http://www.australianprescriber.com/magazine/28/4/91/3/

While the greater *activating effect* of imipramine in comparison to amitryptilin is well demonstrated,...
https://books.google.de/books?id=1O30CAAAQBAJ&pg=PA467&lpg=P...

Suicide attempt and externalizing behaviours in posttraumatic stress disorder (PTSD): Possible role of the *activating effect* of antidepressants.
http://www.researchgate.net/publication/263100066_Suicide_at...

There is a longstanding belief that antidepressants might have an early * activating effect* that gives depressed patients the energy to follow through on suicidal impulses before the mood improvement also provided by antidepressant treatment takes effect.
http://www.bmj.com/content/339/bmj.b2880

This letter discusses the possible role of the *activating effect* of antidepressants in suicide attempt and externalizing behaviours in posttraumatic stress disorder.
http://psycnet.apa.org/index.cfm?fa=search.displayRecord&uid...

Antidepressant treatment also includes relief from overtaxing stresses and ... in suicidal thoughts and behavior and the *activating effect* of some agents.
https://books.google.de/books?id=AmQlBAAAQBAJ&pg=PA407&lpg=P...

A further complication is the *activating effect* of serotonergic drugs, such as fluoxetine...
https://books.google.de/books?id=ubG51n2NgfwC&pg=PA433&lpg=P...

Which one is known to have the least *activating effect*?
https://thinksteroids.com/community/threads/ssri-antidepress...

Bupropion may have an *activating effect*, which some patients may experience as agitation, insomnia, or both, and also may have an appetite suppressant effect.
http://aidsetc.org/printpdf/9430
Selected response from:

uyuni
Local time: 03:57
Grading comment
Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +3drive-enhancing effect
David Tracey, PhD
4 +3activating effect/(properties)
uyuni
3thymeretic effect
Helmut Barz
3 -1synergistic effect
Jakub Rychter, PhD


Discussion entries: 2





  

Answers


16 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
thymeretic effect


Explanation:
This seems to be the term medical papers use (see reference).


    Reference: http://flexikon.doccheck.com/de/Thymeretisch
    Reference: http://link.springer.com/article/10.1007/BF00530680
Helmut Barz
Germany
Local time: 03:57
Works in field
Native speaker of: Native in GermanGerman
Login to enter a peer comment (or grade)

50 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): -1
synergistic effect


Explanation:
Venlafaxine and mirtazapine in combination are increasingly used in clinical practice to treat treatment-refractory depression. Putative efficacy for this combination of antidepressants, beyond that of monotherapy, stems from their synergistic actions.

http://www.ncbi.nlm.nih.gov/pubmed/18330778

Therefore it is thought that mirtazapine enhances noradrenaline
and serotonin
transmission by blockade of these receptors. And thus augmentation of
venlafaxine with mirtazapine is due to a synergistic effect on serotonergic
systems.

http://www.neneccg.nhs.uk/resources/uploads/files/Venlafaxin...


Jakub Rychter, PhD
Spain
Local time: 03:57
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in DutchDutch
PRO pts in category: 4

Peer comments on this answer (and responses from the answerer)
disagree  Steffen Walter: No, 'synergistic' means that the two drugs interact and enhance the desired effect(s) when taken in combination. Nothing to do with 'antriebssteigernd', I'm afraid.
11 mins
  -> Yes, I think you are right. Thanks.
Login to enter a peer comment (or grade)

10 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
drive-enhancing effect


Explanation:
"A moderate anxiolytic effect was found in the nomifensin group, whereas medication had to be discontinued in two desimipramine-treated patients because of its drive-enhancing effect."
http://www.ncbi.nlm.nih.gov/pubmed/786670

"The results showed that moclobemide was as effective as maprotiline (HDRS, Zung SDS); moclobemide appeared to have the same antidepressant and anxiolytic activity, but a stronger drive-enhancing effect."
http://www.ncbi.nlm.nih.gov/pubmed/7954482

--------------------------------------------------
Note added at 1 hr (2015-09-15 14:06:24 GMT)
--------------------------------------------------

Der Grosse Reuter (Springer Universalwörterbuch Medizin Pharmakologie Zahnmedizin)
has "Antriebssteigerung: augmentation of drive"

David Tracey, PhD
Local time: 03:57
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 76

Peer comments on this answer (and responses from the answerer)
agree  rainerc (X)
1 hr
  -> Many thanks, rainerc.

agree  philgoddard
1 hr
  -> Thank you, Phil!

agree  Mack Tillman
17 hrs
  -> Many thanks, Mack!
Login to enter a peer comment (or grade)

2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +3
activating effect/(properties)


Explanation:
In some patients, antidepressants can cause an *activating effect*. This means that a person who before was so depressed that they could hardly get out of bed now has more energy, but is still depressed and irritable.
http://lifepsychiatrist.com/inside-antidepressant-black-box/

This led to the belief that antidepressants may have an *activating effect* that allows patients to follow through on their suicidal impulses.
https://books.google.de/books?id=_8N-nc-GsmgC&pg=PA7&lpg=PA7...

SSRIs may have an initial *activating effect* that can intensify some symptoms of anxiety.
http://www.australianprescriber.com/magazine/28/4/91/3/

While the greater *activating effect* of imipramine in comparison to amitryptilin is well demonstrated,...
https://books.google.de/books?id=1O30CAAAQBAJ&pg=PA467&lpg=P...

Suicide attempt and externalizing behaviours in posttraumatic stress disorder (PTSD): Possible role of the *activating effect* of antidepressants.
http://www.researchgate.net/publication/263100066_Suicide_at...

There is a longstanding belief that antidepressants might have an early * activating effect* that gives depressed patients the energy to follow through on suicidal impulses before the mood improvement also provided by antidepressant treatment takes effect.
http://www.bmj.com/content/339/bmj.b2880

This letter discusses the possible role of the *activating effect* of antidepressants in suicide attempt and externalizing behaviours in posttraumatic stress disorder.
http://psycnet.apa.org/index.cfm?fa=search.displayRecord&uid...

Antidepressant treatment also includes relief from overtaxing stresses and ... in suicidal thoughts and behavior and the *activating effect* of some agents.
https://books.google.de/books?id=AmQlBAAAQBAJ&pg=PA407&lpg=P...

A further complication is the *activating effect* of serotonergic drugs, such as fluoxetine...
https://books.google.de/books?id=ubG51n2NgfwC&pg=PA433&lpg=P...

Which one is known to have the least *activating effect*?
https://thinksteroids.com/community/threads/ssri-antidepress...

Bupropion may have an *activating effect*, which some patients may experience as agitation, insomnia, or both, and also may have an appetite suppressant effect.
http://aidsetc.org/printpdf/9430

uyuni
Local time: 03:57
Specializes in field
Native speaker of: Native in GermanGerman
PRO pts in category: 80
Grading comment
Selected automatically based on peer agreement.

Peer comments on this answer (and responses from the answerer)
agree  David Tracey, PhD
15 hrs
  -> Thank you kindly, David!

agree  Anne Schulz
17 hrs
  -> Danke schön, Anne!

agree  rainerc (X)
23 hrs
  -> Danke Dir, Rainer!
Login to enter a peer comment (or grade)



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