בבדיקה של וורינוסטאט על תאים בצלחת פלסטיק

17:10 Apr 25, 2010
This question was closed without grading. Reason: No acceptable answer

Hebrew to English translations [PRO]
Medical - Medical (general) / Clinical trials
Hebrew term or phrase: בבדיקה של וורינוסטאט על תאים בצלחת פלסטיק
בבדיקה של וורינוסטאט על תאים בצלחת פלסטיק, נגרם נזק לחומר הגנטי (דנ"א) של התאים
Marina Dolinsky (X)
Local time: 00:52


Summary of answers provided
4 +1Vorinostat test on cells in a plastic dish
Lingopro
4Vorinostat
irisgr
4Vorinostat investigation
Textpertise


  

Answers


5 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
Vorinostat


Explanation:
Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC). Histone deacetylase inhibitors (HDI) have a broad spectrum of epigenetic activities.

Vorinostat is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL) when the disease persists, gets worse, or comes back during or after treatment with other medicines.


    Reference: http://en.wikipedia.org/wiki/Vorinostat
irisgr
France
Local time: 23:52
Works in field
Native speaker of: Native in HebrewHebrew, Native in FrenchFrench
PRO pts in category: 20
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5 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
בבדיקה של וורינוסטאט
Vorinostat investigation


Explanation:
Please see the Wikipedia article

http://en.wikipedia.org/wiki/Vorinostat

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Note added at 7 mins (2010-04-25 17:17:48 GMT)
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Lingopro beat me and others to the draw.

Textpertise
United Kingdom
Local time: 22:52
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 80
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4 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
Vorinostat test on cells in a plastic dish


Explanation:
see the link

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Note added at 1 hr (2010-04-25 18:59:07 GMT)
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From the sentence you provided I can only gather that Vorinostat (which is a compound that inhibits histone deacetylases) was tested on cells (taken from a subject) in a plastic dish, as opposed to a glass dish for example, and in this test, the genetic matter (DNA) was damaged.


    Reference: http://en.wikipedia.org/wiki/Vorinostat
Lingopro
Israel
Local time: 00:52
Works in field
Native speaker of: Native in EnglishEnglish, Native in HebrewHebrew
PRO pts in category: 149
Notes to answerer
Asker: Thank you for the translation but I more need the explanation of this test. The link doesn't say anything about test on cells in a plastic dish.

Asker: Also I don't understand well how it connects with other part of the sentence.


Peer comments on this answer (and responses from the answerer)
agree  Textpertise: Sorry crossed with you
1 min
  -> Thank you :-)
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