耐容不能

English translation: unable to tolerate

12:28 Feb 21, 2007
Japanese to English translations [PRO]
Medical - Medical: Pharmaceuticals
Japanese term or phrase: 耐容不能
米国においては 2004 年 2 月に、塩酸イリノテカンとの 併用療法に加え、本剤の単独療法が塩酸イリノテカンに耐容不能となった EGFR 発現転移性結 腸・直腸癌に対して承認された。
Yo Mizuno
Japan
Local time: 23:13
English translation:unable to tolerate
Explanation:
イリノテカンに耐容不能となった
have become unable to tolerate irinotecan
can no longer tolerate irinotecan

Patients who can't tolerate irinotecan or oxaliplatin — For patients who are not appropriate candidates for an aggressive chemotherapy regimen like FOLFOX or FOLFIRI (for example, because of their age, physical condition or coexisting medical problems), intravenous 5-FU plus leucovorin with or without Avastin may be a reasonable, less toxic alternative.
Selected response from:

paul_b
United Kingdom
Local time: 15:13
Grading comment
Thank you!
4 KudoZ points were awarded for this answer



Summary of answers provided
4not tolerable
yuzouren
4intolerant
Tsunehiko Tarumoto
3unable to tolerate
paul_b
3intolerable
lavanya sriram
1drug intolerance
V N Ganesh


  

Answers


15 mins   confidence: Answerer confidence 1/5Answerer confidence 1/5
drug intolerance


Explanation:
just guessing

V N Ganesh
Local time: 19:43
Native speaker of: English
PRO pts in category: 5
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27 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
not tolerable


Explanation:
1

yuzouren
Japan
Local time: 23:13
Works in field
Native speaker of: Native in ChineseChinese
PRO pts in category: 37
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35 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
unable to tolerate


Explanation:
イリノテカンに耐容不能となった
have become unable to tolerate irinotecan
can no longer tolerate irinotecan

Patients who can't tolerate irinotecan or oxaliplatin — For patients who are not appropriate candidates for an aggressive chemotherapy regimen like FOLFOX or FOLFIRI (for example, because of their age, physical condition or coexisting medical problems), intravenous 5-FU plus leucovorin with or without Avastin may be a reasonable, less toxic alternative.


    Reference: http://patients.uptodate.com/topic.asp?file=cancer/13035&tit...
paul_b
United Kingdom
Local time: 15:13
Native speaker of: Native in EnglishEnglish
PRO pts in category: 8
Grading comment
Thank you!
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41 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
intolerable


Explanation:
guess

lavanya sriram
Local time: 23:13
Native speaker of: Native in TamilTamil
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1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5
intolerant


Explanation:
Please look up Erbitux and Irinotecan on the internet. You will find useable sentences. For example, I found one like,"it is also approved for use as a single agent in the treatment of patients with EGFR-expressing, metastatic colorectal cancer who are intolerant to irinotecan-based chemotherapy."



    Reference: http://www.centerwatch.com/patient/drugs/dru850.html
Tsunehiko Tarumoto
United States
Local time: 10:13
Specializes in field
Native speaker of: Native in JapaneseJapanese, Native in EnglishEnglish
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