還元能力が低下する

English translation: reducing ability deteriorates

04:48 Oct 3, 2008
Japanese to English translations [PRO]
Medical - Medical: Pharmaceuticals
Japanese term or phrase: 還元能力が低下する
Referring to coenzymes. This happens in elderly people. Can I say "the body's ability to reduce the coenzyme breaks down"?
casey
United States
Local time: 04:38
English translation:reducing ability deteriorates
Explanation:
or if you like, the body's ability to reduce coenzymes deteriorates.

reduction and oxidation are two sides of the same coin
see:
http://en.wikipedia.org/wiki/Redox

http://en.wikipedia.org/wiki/Coenzyme
Each class of group-transfer reaction is carried out by a particular coenzyme, which is the substrate for a set of enzymes that produce it, and a set of enzymes that consume it. An example of this are the dehydrogenases that use nicotinamide adenine dinucleotide (NADH) as a cofactor. Here, hundreds of separate types of enzymes remove electrons from their substrates and reduce NAD+ to NADH. ~~This reduced coenzyme is then a substrate for any of the reductases in the cell that need to reduce their substrates.~~

Coenzymes are therefore continuously recycled as part of metabolism
Selected response from:

Steven Smith
United Kingdom
Local time: 09:38
Grading comment
Thanks, everybody.
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +1reducing ability decrease
Jason Kang
3 +1reducing ability deteriorates
Steven Smith
3the reduction ability is (could be) deteriorated
yumom
4 -1scavenging ability
patent_pending
Summary of reference entries provided
Krzysztof Łesyk

Discussion entries: 6





  

Answers


55 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +1
reducing ability deteriorates


Explanation:
or if you like, the body's ability to reduce coenzymes deteriorates.

reduction and oxidation are two sides of the same coin
see:
http://en.wikipedia.org/wiki/Redox

http://en.wikipedia.org/wiki/Coenzyme
Each class of group-transfer reaction is carried out by a particular coenzyme, which is the substrate for a set of enzymes that produce it, and a set of enzymes that consume it. An example of this are the dehydrogenases that use nicotinamide adenine dinucleotide (NADH) as a cofactor. Here, hundreds of separate types of enzymes remove electrons from their substrates and reduce NAD+ to NADH. ~~This reduced coenzyme is then a substrate for any of the reductases in the cell that need to reduce their substrates.~~

Coenzymes are therefore continuously recycled as part of metabolism

Steven Smith
United Kingdom
Local time: 09:38
Specializes in field
Native speaker of: Native in EnglishEnglish
PRO pts in category: 40
Grading comment
Thanks, everybody.

Peer comments on this answer (and responses from the answerer)
agree  KathyT
2 hrs
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4 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
reducing ability decrease


Explanation:
First of all, if the text is related to coenzyme, it refers to antioxidation ability. Antioxidation is same as reduction in its final effect.

Second, the reducing(or antioxidation) ability of our body decrease as we grow older. Coenzymes may be of benefit in this situation.

Third, the term 'deteriorate' generally used in medical text to indicate disease state. If the text means 'natural aging process', 'decrease' would be a better wording.

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Note added at 4 hrs (2008-10-03 08:51:43 GMT)
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Ooops, I forgot -s. So, 'reducing ability decreases in the elderly....'

Jason Kang
Canada
Local time: 01:38
Specializes in field
Native speaker of: Native in KoreanKorean
PRO pts in category: 12

Peer comments on this answer (and responses from the answerer)
agree  borha: this is the closest approch in my view, in the sense: "the reducing ability decreases"
3 hrs
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59 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
the reduction ability is (could be) deteriorated


Explanation:
Coenzymes help the catalysis of enzymes for their reduction-oxidization reactions and they provide no action by themselves. It could be considered that the reduction ability with a certain coenzyme is deteriorated in a eldery's body because of the metabolic functions are deteriorated due to senile. As well as, the reduction-oxidizing reaction is caused by an electron transport action between molecules and a certain enzyme accelerates the reaction as a catalyst.

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Note added at 19 hrs (2008-10-04 00:36:29 GMT) Post-grading
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"reduction ability" is also applicable. http://www.chemistry.titech.ac.jp/~ishitani/abstractE.html
It may be prefer to use "the ability to reduce".


    Reference: http://en.wikipedia.org/wiki/Coenzyme
yumom
Local time: 17:38
Works in field
Native speaker of: Native in JapaneseJapanese

Peer comments on this answer (and responses from the answerer)
neutral  Steven Smith: although the process is reduction, in actual usage 'reducing ability' is more usual.
2 hrs
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1 hr   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): -1
還元能力
scavenging ability


Explanation:
"superoxide scavenging ability" の検索結果 約 410 件

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Note added at 1時間 (2008-10-03 06:06:33 GMT)
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"body"と"scavenge"は相性があまり良くないようですので"ability to eliminate"の方がよろしいかも:

"ability to eliminate free radicals" の検索結果 約 1,260 件

"ability to scavenge free radicals" の検索結果 約 7,080 件
"body's ability to scavenge *" の検索結果 約 10 件
"body's ability to scavenge free radicals" の検索結果 約 3 件


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Note added at 1日2時間 (2008-10-04 07:21:46 GMT) Post-grading
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Steven F Smith's counterargument is not logical. That is, he is evading the point of my argument. But anyway the term "scavenge" is not appropriate in the context of the query.

patent_pending
Local time: 17:38
Native speaker of: Native in TetumTetum
PRO pts in category: 16

Peer comments on this answer (and responses from the answerer)
disagree  Steven Smith: Certainly one of the functions of coenzymes is to scavenge free radicals, but I don't think you could say coenzymes themselves are scavenged as part of normal metabolic processes
2 hrs
  -> I don't think "scavenging" is "more of a clean-up operation used with free radicals".
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Reference comments


27 mins
Reference

Reference information:
(hopefully the links work)

This one really is confusing... I'm browsing patent directories now (usually the last resort in my terminology searches) and the patent referenced below (same patent, two language versions) doesn't help much - 還元能力を有する試薬 is translated as "a coenzyme having reducing ability or an agent having oxidizing ability".

Still, even though the oxidization/deoxidation is as confusing as it was before, it seems you can use "reducing" and "coenzymes" in the same sentence ;)

Another confirmation though - are you sure that the body reduces the coenzymes, or is it possible that the ability of the coenzymes to reduce [some other stuff] is affected by age - can't say without more context, but my limited knowledge of biology and medicine tells me it might be the latter...

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Note added at 1 hr (2008-10-03 05:51:10 GMT)
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Well, that shows how limited my knowledge really is, doesn't it?


    Reference: http://www2.ipdl.inpit.go.jp/begin/BE_DETAIL_SIMPLE.cgi?sPos...
    Reference: http://www19.ipdl.inpit.go.jp/PA1/result/detail/main/wAAADga...
Krzysztof Łesyk
Japan
Native speaker of: Native in PolishPolish
PRO pts in category: 4
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