nieefektywna dawka

English translation: non-effective dose (levels)

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Polish term or phrase:nieefektywna dawka
English translation:non-effective dose (levels)
Entered by: Ewa Dabrowska

20:15 Apr 28, 2014
Polish to English translations [PRO]
Science - Chemistry; Chem Sci/Eng
Polish term or phrase: nieefektywna dawka
przebadana wpływ środków (pestycydów) w intoksykacji przez skórę na aktywność esteraz cholinowych krwi i mózgu szczurów oraz ustalono najwyższą nieefektywną dawkę stosowanych pestycydów mierzoną tymi wskaźnikami.

Przy ustalania najwyższej nieefektywnej dawki dwóch preparatów fosforoorganicznych brano pod uwagę korelację między wielkością stosowanej dawki pestycydu a aktywnością esteraz cholinowych we krwi i mózgu.

Czy "najwyższa nieefektywna dawka" to "maximum exposure limit"? z definicji wygląda na to, że tak, ale chciałam się upewnić, ze względu na słowo "nieefektywna".
Ewa Dabrowska
United Kingdom
Local time: 07:47
non-effective dose (levels)
Explanation:
I see this in connection with pesticide studies on rats. Links later.

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Note added at 4 hrs (2014-04-29 00:52:11 GMT)
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Neurotoxicological and Statistical Analyses of a Mixture of Five Organophosphorus Pesticides Using a Ray Design


The ratio of the five pesticides (full ray) reflected the relative dietary exposure ... rats at the time of peak effect following a single oral dose, and then ... of the 5-OP mixture, which contained non-effective dose levels of each of the components. The predicted effective doses (ED20, ED50) were about half that

Greater-than-additive responses (synergism) were observed at the lower doses of the 5-OP mixture, which contained non-effective dose levels of each of the components

http://toxsci.oxfordjournals.org/content/86/1/101.abstract

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Note added at 4 hrs (2014-04-29 00:55:56 GMT)
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FAO Panel of Experts on Pesticide Residues and the Environment, Food and ... lethal doses (LD50s) for azinphos-methyl and profenofos in rats were 13 mg/kg bw ... On the other hand, the daily non-effective dose of profenofos was about 30 ...

Pesticide residues in food 2007. Report of the Joint Meeting of the FAO ...
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Over the long period of time, pesticides containing dioxins (2,4,5-Т, copper ... species of hamsters, about 70 mcg/kg for monkeys and 25-45 mcg/kg for rats. ... For monkeys, maximum non-effective dose as to teratogenic effect makes up 0
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The inhalation LC50 (6 hours) of amitraz for rats is 65 mg/l of air. ... Amitraz was a restricted use pesticide in 1985 because some studies .... to amitraz was assumed to be 0.125 mg/kg (highest non effective dose tested) (24). 2
http://www.webmedcentral.com/article_view/4121
Selected response from:

Frank Szmulowicz, Ph. D.
United States
Local time: 02:47
Grading comment
thank you
4 KudoZ points were awarded for this answer



Summary of answers provided
2 +2non-effective dose (levels)
Frank Szmulowicz, Ph. D.
3ineffective dose
jacek o


Discussion entries: 1





  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5
ineffective dose


Explanation:
The highest ineffective dose in respect of toxic effects or depression of blood... ( http://www.inchem.org/documents/jmpr/jmpmono/v065pr34.htm )

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Note added at 1 hr (2014-04-28 21:57:29 GMT)
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The highest ineffective dose in respect of toxic effects or depression of blood cholinesterase activity was 1.0 mg/kg body-weight/day

jacek o
Local time: 08:47
Specializes in field
Native speaker of: Native in PolishPolish
PRO pts in category: 124
Login to enter a peer comment (or grade)

37 mins   confidence: Answerer confidence 2/5Answerer confidence 2/5 peer agreement (net): +2
non-effective dose (levels)


Explanation:
I see this in connection with pesticide studies on rats. Links later.

--------------------------------------------------
Note added at 4 hrs (2014-04-29 00:52:11 GMT)
--------------------------------------------------

Neurotoxicological and Statistical Analyses of a Mixture of Five Organophosphorus Pesticides Using a Ray Design


The ratio of the five pesticides (full ray) reflected the relative dietary exposure ... rats at the time of peak effect following a single oral dose, and then ... of the 5-OP mixture, which contained non-effective dose levels of each of the components. The predicted effective doses (ED20, ED50) were about half that

Greater-than-additive responses (synergism) were observed at the lower doses of the 5-OP mixture, which contained non-effective dose levels of each of the components

http://toxsci.oxfordjournals.org/content/86/1/101.abstract

cccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccc

--------------------------------------------------
Note added at 4 hrs (2014-04-29 00:55:56 GMT)
--------------------------------------------------

FAO Panel of Experts on Pesticide Residues and the Environment, Food and ... lethal doses (LD50s) for azinphos-methyl and profenofos in rats were 13 mg/kg bw ... On the other hand, the daily non-effective dose of profenofos was about 30 ...

Pesticide residues in food 2007. Report of the Joint Meeting of the FAO ...
cccccccccccccccccccccccccccccccccccccccccccccccccccccccccccc

Over the long period of time, pesticides containing dioxins (2,4,5-Т, copper ... species of hamsters, about 70 mcg/kg for monkeys and 25-45 mcg/kg for rats. ... For monkeys, maximum non-effective dose as to teratogenic effect makes up 0
ccccccccccccccccccccccccccccccccccccccccccccccccccc

The inhalation LC50 (6 hours) of amitraz for rats is 65 mg/l of air. ... Amitraz was a restricted use pesticide in 1985 because some studies .... to amitraz was assumed to be 0.125 mg/kg (highest non effective dose tested) (24). 2
http://www.webmedcentral.com/article_view/4121

Frank Szmulowicz, Ph. D.
United States
Local time: 02:47
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in PolishPolish
PRO pts in category: 252
Grading comment
thank you

Peer comments on this answer (and responses from the answerer)
agree  mike23: I can't smell a rat here
6 mins
  -> James Cagney in reverse. Dziękuję Michale.

agree  Deboren
9 hrs
  -> Thank you for your kind consideration, Deboren.
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