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  3. Medical: Pharmaceuticals

teste de log-rank estratificado com error de tipo-1 unilateral i = 0,025

English translation: stratified log-rank test with one-sided type-I error rate i = 0.025

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Portuguese term or phrase:teste de log-rank estratificado com error de tipo-1 unilateral i = 0,025
English translation:stratified log-rank test with one-sided type-I error rate i = 0.025
Entered by: Roxane Dow

19:11 Apr 19, 2017
Portuguese to English translations [PRO]
Medical - Medical: Pharmaceuticals / Statistical tests
Portuguese term or phrase: teste de log-rank estratificado com error de tipo-1 unilateral i = 0,025
From Methods and Data Analysis section of Ethics Committee decision (describing statistics used to analyze clinical trial data) in Brazil

Full sentence:
Pelo menos XXX eventos são necessários para garantir um poder de 90% de detecção da diferença na SG pelo teste de log-rank estratificado com erro do tipo-1 unilateral i = 0,025, e taxa de risco real subjacente de 0,65.

I know that this is "stratified log-rank test" and "type I error", but what does "unilateral" (one-sided) modify?

I think the "i" is a typo, and should probably be "p".

Thanks for any help you can offer! I would also appreciate any references to basic statistics textbooks that might help.
Roxane Dow
United States
Local time: 19:36
stratified log-rank test with one-sided type-I error rate i = 0.025
Explanation:
"One-sided" refers to the statistic's distribution. Every statistical test is associated with a distribution that is used to calculate significance and error. As this sentence focuses on the error rate, I would write "stratified log-rank test with one-sided type-I error rate i = 0.025"

The "i" is NOT a p-value. You cannot calculate a p-value without actual data, which you don't have at this point.
Selected response from:

Paulo César Mendes MD, CT
United States
Local time: 18:36
Grading comment
Many thanks, Paulo!
4 KudoZ points were awarded for this answer



Summary of answers provided
4one-sided stratified log-rank test at a type I error rate of i = 0.025
Rafael Sousa Brazlate
4stratified log-rank test with one-sided type-I error rate i = 0.025
Paulo César Mendes MD, CT


Discussion entries: 6





  

Answers


29 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5
one-sided stratified log-rank test at a type I error rate of i = 0.025


Explanation:
As used in the following document:

https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/2015...

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Note added at 32 mins (2017-04-19 19:44:18 GMT)
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I think this i can be an error as well; have you looked at the rest of the document?

Also, I believe one-sided modifies the test. At least this is the way see it written most often in the protocols I translate from English into Portuguese.

--------------------------------------------------
Note added at 33 mins (2017-04-19 19:45:00 GMT)
--------------------------------------------------

One-sided vs. two-sided tests:

http://onbiostatistics.blogspot.com.br/2016/03/one-sided-ver...

Rafael Sousa Brazlate
Brazil
Local time: 20:36
Specializes in field
Native speaker of: Portuguese
PRO pts in category: 23
Login to enter a peer comment (or grade)

5 days   confidence: Answerer confidence 4/5Answerer confidence 4/5
stratified log-rank test with one-sided type-I error rate i = 0.025


Explanation:
"One-sided" refers to the statistic's distribution. Every statistical test is associated with a distribution that is used to calculate significance and error. As this sentence focuses on the error rate, I would write "stratified log-rank test with one-sided type-I error rate i = 0.025"

The "i" is NOT a p-value. You cannot calculate a p-value without actual data, which you don't have at this point.


    https://en.wikipedia.org/wiki/Log-rank_test
Paulo César Mendes MD, CT
United States
Local time: 18:36
Specializes in field
Native speaker of: Portuguese
PRO pts in category: 12
Grading comment
Many thanks, Paulo!
Login to enter a peer comment (or grade)



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