Glossary entry (derived from question below)
English term or phrase:
human PBMC reconstituted NSG mice model
Russian translation:
мыши NSG с привитыми МКПК человека
Added to glossary by
Wolfskin
Oct 25, 2018 07:08
5 yrs ago
2 viewers *
English term
human PBMC reconstituted NSG mice model
English to Russian
Law/Patents
Biology (-tech,-chem,micro-)
Получение триспецифичных антител
For the efficacy study using hu-PBMC NSG mice, 8-10 week old NSG mice (Cat.
No:
005557, NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) were purchased from The Jackson Laboratory (Maine, USA).
Each mouse was innoculated with 5x106 tumor cells mixed in Matrigel (BD Biosciences) (50% v/v).
Once tumor size reached the range of 50-100 mm3, 10x106 human PBMCs from a healthy donor were reconstituted to each mouse.
Human cell reconstitution was validated the next day.
Once tumor size reached the range of 100-150 mm3, mice were selected and randomized into each group for study.
И еще - A 2nd in vivo study using human PBMC reconstituted NSG mice model inoculated with human HER2+ breast cancer line BT474 was also done (FIGS. 20A-20H).
Интересует именно reconstituted в данном контексте.
Спасибо
No:
005557, NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) were purchased from The Jackson Laboratory (Maine, USA).
Each mouse was innoculated with 5x106 tumor cells mixed in Matrigel (BD Biosciences) (50% v/v).
Once tumor size reached the range of 50-100 mm3, 10x106 human PBMCs from a healthy donor were reconstituted to each mouse.
Human cell reconstitution was validated the next day.
Once tumor size reached the range of 100-150 mm3, mice were selected and randomized into each group for study.
И еще - A 2nd in vivo study using human PBMC reconstituted NSG mice model inoculated with human HER2+ breast cancer line BT474 was also done (FIGS. 20A-20H).
Интересует именно reconstituted в данном контексте.
Спасибо
Proposed translations
(Russian)
4 | мыши NSG с привитыми МКПК человека | Natalie |
Proposed translations
38 mins
Selected
мыши NSG с привитыми МКПК человека
В этом контексте слово reconstituted означает дословно "восстановленный", в том смысле, что иммунная система иммунодефицитных мышей линии NSG (NOD/SCID Gamma) была восстановлена путем трансплантации МКПК человека.
РВМС = МКПК (мононуклеарные клетки периферической крови [человека])
РВМС = МКПК (мононуклеарные клетки периферической крови [человека])
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