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attached
75 grades
Apr 11, 2009 15:25
15 yrs ago
English term

how for will this mutation be

English Medical Genetics
How far will this mutation be in my family kinship?

Again, I wonder if you could help me with the most appropriate words for this questions, since it makes no sense to me.

This is an example among many of the questions patients usually ask in genetic counselling consultations. This patient seems to be quite worried about passing their mutated genes on to their descendents.

Thansk
Responses
3 To how many generations will I pass this mutation
3 +4 how many generations
4 what is the extent/spread of this mutation?
4 How long will this genotype occur in my family bloodline?
3 How far does thi mutation reach amongst my (existing) family

Discussion

Gary D Apr 12, 2009:
How far will this mutation be in my family kinship Am I attached to my family diseases? = Is there a family connection with the disease?

How far will this mutation be in my family kinship. = How deeply into my family does this mutation occur? (How many of my other family members will be effected)

Mum's side, Dad's side of the family, My parents, his/ her parents, my kids, my sisters / brothers kids... Not necessarily how many generations.

Lirka Apr 11, 2009:
Thanks for the additional info. Now it's easier. Please see my answers
Daisymiller (asker) Apr 11, 2009:
a tough job!! :) :) Thank you for your support!!
Allow me to provide you with an extract of the original text:

"For clients, genetic counselling is a complex medical procedure, simultaneously affecting the individual and its family, which is perceived through the collection of personal and family cancer history. Clients are usually informed about hereditary inheritance patterns implicated in family illnesses in their first consultation. Therefore, clients view genetic counselling as a family matter, and usually associate it with heredity based on two perspectives: i) the fear of having inherited a pathogenic mutation from their ancestors (Am I attached to my family diseases?); and ii) the fear of passing the mutated gene on to their descendants (How far will this mutation be in my family kinship?). Several emotions emerge in this context, including a sense of guilt, fear, and impotence/helplessness attached to a feeling of “loss of control”.

Hope it can be of help...

This research clearly focus on cancer, and the importance of genetic counselling for patients (called clients here) and family.

Lirka Apr 11, 2009:
I feel your pain! These questions are so incredibly POORLY worded that one cannot conclude what they intend to say. I am an MD and a biologist dealing with genetics on a daily basis, but cannot conclude much. All is possible. It could be that the patient seeks to know how many other members of the family are affected, or possibly carriers, or what the likelihood of transmitting the disease ( or the carrier state) to the next generation is... If you can provide more context for this specific questions, maybe we can jointly figure it out :)

Responses

2 hrs
Selected

To how many generations will I pass this mutation


Or: How far down the family tree will this mutation be passed?

Perhaps even: How many generations will be the carriers of this mutation? ( less suitable for laymen)

In any case, the less-medical term ( yet still medical enough) would be TO PASS
Something went wrong...
2 KudoZ points awarded for this answer.
23 mins

How far does thi mutation reach amongst my (existing) family

..Rather clumsily phrased above, but i couldnt seem to get it clearer.

My understanding is essentially that the people would be asking how many members of the family carry the mutated gene. (i.e. Cousins, 2nd cousins, aunts, uncles etc...)

I dont know what context this is in exactly, but i have been in situations where people marrying within their extended family (e.g. marrying cousins or 2nd cousins etc...) want to know whether they are both carrying a mutated gene or not, (for obvious reasons- if they are both carriers then the likelyhood of any offspring developing the related mutation jump significantly...

In any case, my impression is they would be asking on a horizontal scope rather than a vertical one.

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Note added at 24 mins (2009-04-11 15:49:58 GMT)
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(And of course, in the definition i meant to write "THIS", not "THI"....sticky keys, sorry..!

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Note added at 27 mins (2009-04-11 15:53:34 GMT)
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Or maybe, to get away from the clumsiness above "How far-reaching is this mutation within my family"
Peer comment(s):
neutral Lirka : we don't know if they mean vertical or horizontal spread
1 hr
True, it is unclear, the wording to me doesn't make much sense, i have to say! It was the way for me that made the most sense with the 'how far' bit...but who knows what is intended!
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1 hr

what is the extent/spread of this mutation?

...in my family.

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Note added at 1 hr (2009-04-11 17:11:15 GMT)
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If the person is receiving genetic counselling and has limited ability to formulate his/her questions in English, I think it is important that the question should be broadly interpreted to ensure that the issues they are worried about are covered in the counselling.
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+4
9 mins

how many generations

For how many generations will my family carry this mutation?

How many generations of my will family carry this mutation?

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Note added at 2 hrs (2009-04-11 17:26:38 GMT)
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The point here is that there is no way to know, these are mere guesses, and the only way to know is to go back to the original, whatever that may be, or ask the author. Short of that, good luck
Peer comment(s):
agree Jack Doughty
0 min
agree Janet Ross Snyder
11 mins
neutral K. Ganly (X) : given it is in genetic counselling, i think the question is more likely to be to do with how far-reaching is the mutation amongst extended family, (i.e. horizontally, rather than vertically)...
17 mins
agree Michal Berski : generations of my descendants - after explanations
40 mins
neutral Lirka : carrying the mutation and expressing it are two different things; we don't know what they meant
1 hr
agree Ana L Fazio-Kroll : How far WILL this mutation BE...they are talking about the FUTURE Generations....
6 hrs
Something went wrong...
6 hrs

How long will this genotype occur in my family bloodline?

How long will this genotype occur in my family bloodline?

I wouldn't call it a mutation as it would be an incorrect word for use in genetics.
Something went wrong...
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