English to Russian Medical Medical: Pharmaceuticals

Anti-VEGF therapy has revolutionized the treatment of neovascular AMD and other VEGF-related retinal diseases, since the introduction of ranibizumab, a recombinant monoclonal antibody fragment against all isoforms of VEGF-A. Ranibizumab is a humanized monoclonal antibody fragment produced in Escherichia coli cells by recombinant DNA technology. Ranibizumab is a 214- AA residue light chain linked by a disulfide bond at its C- terminus extremity to the 231 AA residues N-terminal segment of the heavy chain.