Broad 在此的意思，比較不確定。

以下僅供參考:

“Latanoprost是用於降低眼內壓的第一個前列腺素衍生物，1996年首度在美國上市，FDA最初所核准的適應症為第二線用藥，而根據最近一項長達五年的安全性研究，FDA最近終於核准Latanoprost可作為第一線的治療用藥。”

“Latanoprost was introduced in the United States in 1996 as the first prostaglandin-based IOP-lowering medication, and the FDA initially approved the medication for second-line use. The new first-line indication is supported by five-year safety data on latanoprost submitted to the FDA.”
http://www.24drs.com/professional/list/content.asp?x_classno...
“這個複方單錠之前僅被核准用於第二線治療。”
“The combination tablet previously was approved for second-line use only.”
“目前健保給付常將標靶藥物視為第一線治療失效後的二線用藥，近年來…在肺線癌 方面，廣泛用為第一線藥物。”
http://www.epochtimes.com/b5/7/5/3/n1698738.htm


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Note added at 2 hrs (2009-08-12 05:44:22 GMT)
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http://www.24drs.com/professional/index.asp