English to Portuguese Medical Medical: Pharmaceuticals

. In some cases, these cracks may not be initially present on the exterior of the tablet and hence may not be visible to the naked eye but under conditions of stress such as heat and shear in a coating pan, the cracks can propagate towards the exterior and present themselves to the naked eye. A complex interplay of roller compaction pressure, tamp force and tamp positioning optimization during bilayer compression was critical to resolving the bilayer cracking. The second layer of lamivudine and tenofovir disoproxil fumarate is prone to roll sticking during roller compaction due to the high drug loadings and the inherent sticking propensity of tenofovir.