English to Russian Medical Medical: Pharmaceuticals микроядерный тест

Raltegravir has been tested for genotoxicity in four GLP studies. Raltegravir did not show any
mutagenic/genotoxic effects in the (i) in vitro bacterial mutation assay (Salmonella typhimurium
strains and Escherichia coli strain); (ii) alkaline elution/rat hepatocyte assay (Primary Rat
hepatocytes); (iii) chromosome aberration assay (Chinese Hamster Ovary cells); (iv) in vivo in the
mouse micronucleus assay (Mouse/CRL). All studies were conducted using a range of doses; at the
highest dose, there was evidence of cytotoxicity and/or drug insolubility. The results are uniformly
negative, indicating the absence o f genotoxic potential for raltegravir.

теоретически догадываюсь, что это наименование клеточной линии, но хотелось бы уточнить - уж очень важный документ-с.