Glossary entry

English term or phrase:

low substituted

Serbian translation:

niskog stepena supstitucije

Added to glossary by Aleksandar Skobic
May 28, 2011 10:47
12 yrs ago
1 viewer *
English term

low substituted

English to Serbian Medical Medical: Pharmaceuticals
Each gastro-resistant hard capsule contains 20mg omeprazole and excipient: hypromel-lose, disodium hydrogen phosphate dehydrate, sodium lauryl, sulphate, low substituted, hydroxyl propyl cellolose, sugar spheres, titanium dioxide (E171), magnesium carbonate light, talc, methacrylic acid copolymer type.

Proposed translations

+3
2 hrs
Selected

niskog stepena supstitucije

Ne bi trebalo da ima zarez, to je hidroksipropil celuloza niskog stepena supstitucije, na engleskom L-HPC. Ali ovo je samo moje objašnjenje, nažalost ne znam tačno kako farmaceuti to zovu kod nas.

http://www.galenika.rs/index.php?option=com_content&task=vie...
Sadržaj pomoćnih supstanci:
Sadržaj jezgra tablete: mikrokristalna celuloza; laktoza, monohidrat; skrob, kukuruzni, preželatinizovan; natrijum-skrob glikolat; magnezijum-stearat
Sadržaj filma-Opadry white: hidroksipropil celuloza; hipromeloza; titan-dioksid (E171)

http://www.doiserbia.nb.rs/img/doi/0367-598X/2010/0367-598X1...
Uzorci karboksimetil-skroba imaju stepene supstitucije 0,50 i 0,70 i molarne mase 5,06×10o6 i 15,4×10o6 g/mol, a uzorak katjonskog skroba ima stepen supstitucije 0,30 i molarnu masu od 19,2×10o6 g/mol.
Peer comment(s):

agree ipv : ispričavam se, nekakako u isto vrijeme smo predložili odgovor :)
9 mins
:))
agree Natasa Djurovic
21 hrs
agree Nikola Bubić
1 day 18 hrs
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4 KudoZ points awarded for this answer.
+1
2 hrs

nisko supstituirana

moglo bi biti, ali naglašavam da je confidence level 1 :)
Pomoćne tvari su: míkrokristalna celuloza, manitol, krospovidon, nisko supstituirana hidroksipropilceluloza, aspartam, kalcij-silikat..
www.almp.hr/upl/lijekovi/PIL/UP-I-530-09-06-01-30.pdf

(LH-21); hidroksipropilceluloza, nisko supstituirana(LH-11); talk, makrogol ...
www.almp.hr/upl/lijekovi/PIL/UP-I-530-09-07-01-517.pdf

Peer comment(s):

agree Dragana Samardžijević : "... manitol, nisko-supstituiranu hidroksipropilcelulozu i barem jedan lubrikant izabran između makrogola, talka i hidriranog ricinusovog ulja. ..."www.dziv.hr/webcontent/file_library/izvori_inf/.../05_2010.... (mada se ne može ući, postojao je trag)
19 mins
hvala
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2 days 6 hrs

nizak stepen zamene u hidroksipropil celulozi

1)Product name:Low-substituted hydroxypropyl cellulose
Product description:The present invention provides low-substituted hydroxypropyl cellulose exhibiting good granulation characteristics and tablet properties. Specifically, there is provided low-substituted hydroxypropyl cellulose having a hydroxypropoxyl content in the range of 5.0 to 16.0% by weight and an apparent average degree of polymerization in the range of 350 to 700
2)Hydroxypropyl cellulose (HPC) is a derivative of cellulose with both water solubility and organic solubility. It is used as a topical ophthalmic protectant and lubricant.
HPC is an ether of cellulose in which some of the hydroxyl groups in the repeating glucose units have been hydroxypropylated forming -OCH2CH(OH)CH3 groups using propylene oxide. The average number of substituted hydroxyl groups per glucose unit is referred to as the degree of substitution (DS). Complete substitution would provide a DS of 3. Because the hydroxypropyl group added contains a hydroxyl group, this can also be etherified during preparation of HPC. When this occurs, the number of moles of hydroxypropyl groups per glucose ring, moles of substitution (MS), can be higher than 3.

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