English to Spanish Science Medical: Pharmaceuticals

was suspended in 1% hydroxyethyl cellulose and administered by oral gavage to 8 chronically instrumented conscious male Wistar rats per group at a single dose of 0 (vehicle control), 10, 30 and 100 mg/kg (0, 60, 180 and 600 mg/m2). Systolic arterial pressure, heart rate, temperature, motility, respiration rate and tidal volume were recorded predose at baseline and postdose for intervals 10 min 2 h and 2 7 h after dosing.