expansion (of T cells)

English translation: proliferation

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:expansion (of T cells)
Selected answer:proliferation
Entered by: Neil Ashby

09:01 Nov 7, 2022
English language (monolingual) [PRO]
Science - Biology (-tech,-chem,micro-) / immunology
English term or phrase: expansion (of T cells)
Hello!
I'm looking for the meaning of the word 'expansion' ('expand', 'expanded' etc.) in the context of cells. What does e.g. 'expanding of T cells' mean exactly? Is it just 'making T cells proliferate' or does it convey something more?
Thank you for your help!
WeronikaM
Poland
Local time: 12:23
proliferation
Explanation:
As always, the actual sentence with the expression helps.

I don't think it means the cells grow in size, but rather they grow in number, but without any context, it's difficult to be sure.
Selected response from:

Neil Ashby
Spain
Local time: 12:23
Grading comment
Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer



SUMMARY OF ALL EXPLANATIONS PROVIDED
2 +4proliferation
Neil Ashby
5expansion
Zheng Ma


Discussion entries: 2





  

Answers


14 mins   confidence: Answerer confidence 2/5Answerer confidence 2/5 peer agreement (net): +4
expansion (of t cells)
proliferation


Explanation:
As always, the actual sentence with the expression helps.

I don't think it means the cells grow in size, but rather they grow in number, but without any context, it's difficult to be sure.

Neil Ashby
Spain
Local time: 12:23
Works in field
Native speaker of: English
PRO pts in category: 4
Grading comment
Selected automatically based on peer agreement.
Notes to answerer
Asker: Thank you for your answer. Here is some context: https://patents.google.com/patent/US6352694B1/en : Antigen-specific T cells can be expanded in vitro for use in adoptive cellular immunotherapy in which infusions of such T cells have been shown to have anti-tumor reactivity in a tumor-bearing host. Adoptive immunotherapy has also been used to treat viral infections in immunocompromised individuals. Techniques for expanding human T cells in vitro have relied on the use of accessory cells and exogenous growth factors, such as IL-2. The use of IL-2 and, for example, an anti-CD3 antibody to stimulate T cell proliferation is known to expand the CD8+ subpopulation of T cells.


Peer comments on this answer (and responses from the answerer)
agree  Kimberly Vanzi: It means grow in numbers
3 hrs
  -> Thanks Kimberly

agree  philgoddard: I think so, since it says proliferation in the next sentence. But expansion is ambiguous.
4 hrs
  -> Cheers Phil

agree  David Gibney
1 day 6 hrs
  -> Thanks David.

agree  Lirka
1 day 16 hrs
Login to enter a peer comment (or grade)

26 mins   confidence: Answerer confidence 5/5
expansion


Explanation:
Chimeric antigen receptor (CAR) T cell therapy has advanced into commercially available treatments that have driven an influx of companies into the immunotherapy landscape. In a standard workflow, a patient’s (autologous) or donor’s (allogeneic) genetically engineered T cells must be expanded ex vivo for clinical use. Typically, T cell expansion is the longest and one of the most critical phases in the CAR T workflow.

Engineered T cells are sensitive to their microenvironment and growth conditions. These responses can lead to potential undesirable cellular changes, which pose production and quality control challenges that could ultimately delay patient treatment.

One of the main objectives during the expansion phase is to maintain “younger”, less differentiated memory cell phenotypes. Figure 1 illustrates the spectrum of T cell differentiation with the less differentiated, most therapeutically desirable central memory T cells (TCM) on the left and less desirable, more mature effector memory T cells (TEM) and effector T cells (TEFF) on the right. Surface markers such as CD62L, CCR7, and CD28 are not present when T cells differentiate and transition toward the TEFF cell populations and become less efficacious.


    https://www.thermofisher.com › cell-therapy-handbook
Zheng Ma
China
Local time: 18:23
Native speaker of: Native in ChineseChinese

Peer comments on this answer (and responses from the answerer)
neutral  philgoddard: So expansion means expansion.
10 hrs
  -> Sure. Thanks, Philgoddard!
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