Glossary entry (derived from question below)
English term or phrase:
median lifetime cumulative dose
English answer:
total amount of drug taken during the patient's life up to...
Added to glossary by
Jörgen Slet
Mar 14, 2004 23:01
20 yrs ago
5 viewers *
English term
Estonia
19 years of biomedical translation
Native in: Estonian 
Works in: English to Estonian, Estonian to English
median lifetime cumulative dose
English
Medical
Medical: Pharmaceuticals
The text refers to a cardiotoxic drug:
"The median lifetime cumulative dose of XXX to a cardiac event was nnn mg..."
What does the "lifetime" refer to here ?
"The median lifetime cumulative dose of XXX to a cardiac event was nnn mg..."
What does the "lifetime" refer to here ?
Responses
| 4 +4 | comment |
David Sirett
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| 4 +1 | see comment |
Hacene
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| 4 +1 | useful example supporting David's comment |
DGK T-I
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Responses
+4
1 hr
Selected
comment
It means the total amount of XXX taken during the patient's life up to the time a cardiac event occurred.
4 KudoZ points awarded for this answer.
Comment: "The timespan is in years, so this clearly seems to be the case. Thanks everybody, esp.dr. Giuli who deserves points, too - I just don't have more to spare."
+1
23 mins
see comment
the average span of time the drug is currently still active in the system when there is a regular intake of the said drug.
Peer comment(s):
| disagree |
claudia16 (X)
: it refers to de cumulative dose,not to the time the drug stays active in circulation. the enphasis is on the build up of the drug in the body because it is toxic to the heart (wrong end of the stick)
9 mins
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did you read my comment? especially the part: when there is a regular intake of the said drug? + if you are so sure, why don't you submit an answer?
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| agree |
Vicky Papaprodromou
29 mins
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cheers Vicky
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| agree |
knipe
: lifetime in this case is the time the drug is active. drugs can have a half-life etc. This is important to be able to adjust doses and avoid overdoses.
7 hrs
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cheers
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+1
10 hrs
useful example supporting David's comment
"According to criteria laid out in the FDA’s approval of Novantrone for MS, the drug should only be used in those with normal cardiac function, once every three months at a dose of 12mg/m2. The lifetime cumulative dose is limited to 140 mg/m2. For most, this would mean that after about 8 to 12 doses over 2 to 3 years, no more drug should be taken...."
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Note added at 10 hrs 46 mins (2004-03-15 09:48:08 GMT)
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http://www.mult-sclerosis.org/ news/Jan2003/TrialResultsofNovantronemitoxantroneforWorseningMS.html
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Note added at 10 hrs 47 mins (2004-03-15 09:49:11 GMT)
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http://www.mult-sclerosis.org/news/Jan2003/TrialResultsofNov...
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Note added at 10 hrs 46 mins (2004-03-15 09:48:08 GMT)
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http://www.mult-sclerosis.org/ news/Jan2003/TrialResultsofNovantronemitoxantroneforWorseningMS.html
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Note added at 10 hrs 47 mins (2004-03-15 09:49:11 GMT)
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http://www.mult-sclerosis.org/news/Jan2003/TrialResultsofNov...
Reference:
www.mult-sclerosis.org/ news/Jan2003/TrialResultsofNovantronemitoxantroneforWorseningMS.html
Peer comment(s):
| agree |
claudia16 (X)
: I rest my case, that the enphasis is on the drug as it builds up and that is what is measuredm, NOT how long it stays active in circuation.
14 hrs
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absolutely:the total quantity that has been taken in a lifetime,so far(or that should be taken in a whole lifetime) - it is different from(although easy to confuse with) the 'half-life of a substance'etc(median being the mid-value of a sample)
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