Glossary entry

Russian term or phrase:

фигуры апоптоза

English translation:

apoptotic figures

Added to glossary by Dylan Edwards
Sep 17, 2020 12:15
3 yrs ago
18 viewers *
Russian term

фигуры апоптоза

Russian to English Medical Medical (general)
При ЛПКР II степени тяжести выявлена неравномерная пролиферация клеток эпидермиса с формироваием гипертрофических псориазоподобных акантотических выростов, слабо выраженная вакуолизация кератиноцитов, немногочесленные *фигуры апоптоза*, дис- и гиперкератоз, дилатация микрососудов сосочкового слоя дермы.
Votes to reclassify question as PRO/non-PRO:

Non-PRO (1): TechLawDC

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Discussion

Dylan Edwards (asker) Sep 18, 2020:
Thank you, Igor, for the explanation.
Igor Andreev Sep 17, 2020:
Термин фигуры пришел из цитологии - это характерные образования или картины, если можно так сказать.
В частности, распространен термин "фигуры митозов"
svetlana cosquéric Sep 17, 2020:
to Dylan ...apoptosis produces cell fragments called apoptotic bodies...
https://en.wikipedia.org/wiki/Apoptosis
Oleg Lozinskiy Sep 17, 2020:
And even 'figures of apoptosis'... ...(whatever it means) are quite popular:

- Representative figures of apoptosis assay on AZ521 and C2C12 cells were shown in left panel, and the percentage and SD of early apoptosis (bottom right ...

- (A) Figures of apoptosis by flow cytometry. a, b, c, d, e and f indicate control, mock, pCMV6, MYC-KL, shRNAc and sh-2 groups, respectively. (B) The data ...

- The morphological figures of apoptosis were monitored by fluorescence microscopy after staining with Hoechst 33258. Images are ...

- These cells also present characteristic figures of apoptosis (data not shown). Therefore, to compare their sensitivity to apoptosis, REG ...

Etc., etc.
https://www.google.ru/search?newwindow=1&biw=1045&bih=730&tb...
Oleg Lozinskiy Sep 17, 2020:
Example of usage Специфика ладонно-подошвенной кожной реакции, индуцированной мультикиназными ингибиторами: клинические, гистологические и ультразвуковые характеристики

При патоморфологическом исследовании пораженных тканей выявлены неравномерная пролиферация клеток эпидермиса с формированием гипертрофических псориазоподобных акантотических выростов, слабо выраженная вакуолизация кератиноцитов, немногочисленные фигуры апоптоза, дис- и гиперкератоз, дилатация микрососудов сосочкового слоя дермы.

Specificity of hand-foot skin reaction induced by multikinase inhibitors: clinical, histological and ultrasound characteristics

Pathomorphological examination revealed irregular epidermal proliferation with hypertrophic psoriasiform acanthosis, minimal keratinocyte vacuolization, few apoptotic figures, dyskeratosis, hyperkeratosis and microvessel dilation in the papillary dermis.
https://www.google.ru/url?sa=t&rct=j&q=&esrc=s&source=web&cd...
Oleg Lozinskiy Sep 17, 2020:
As in addition to 'апоптотические фигуры' different Russian-speaking authors also use 'апоптозные/апоптотические тела/тельца' (all four possible word units are readily googlable), I'd rather keep as close to the source text as possible and make use of the apoptotic 'figures' or 'features'.
Dylan Edwards (asker) Sep 17, 2020:
I wanted to make sure about this term because I saw many examples of the term "apoptotic bodies".
"Фигуры" is more general, it seems.

Proposed translations

+2
10 mins
Selected

apoptotic features

*

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Note added at 16 мин (2020-09-17 12:32:15 GMT)
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Apoptosis is characterised by a series of typical morphological features, such as shrinkage of the cell, fragmentation into membrane-bound apoptotic bodies and rapid phagocytosis by neighbouring cells.

TUNEL-positive cardiomyocytes show morphological features of apoptosis and the typical ladder pattern in DNA electrophoresis.
https://academic.oup.com/cardiovascres/article/45/3/528/3044...

- In cardiomyocytes, several apoptotic features have been reported at the light microscopic level (Fig. 1) (review in [29]). These include condensation of nuclei, ...

- Finally, a caspase 3 knock-out was characterized by ectopic cell masses in the brain and abnormal apoptotic features such as membrane blebbing or nuclear ...

- Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity. Author links open overlay ...

- Cell death with predominant apoptotic features in Saccharomyces cerevisiae mediated by deletion of the histone chaperone ASF1/CIA1.

- Analysis of apoptotic features during cardiogenesis in embryonic stem cells.

- Apoptotic features of selective neuronal death in ischemia, epilepsy and gpI20 toxicity.

- Cell death with predominant apoptotic features in Saccharomyces cerevisiae mediated by deletion of the histone chaperone ASF1/CIA1.

- HT appears a valid approach to further characterize well‐known apoptotic features such as cell blebbing, chromatin condensation, micronuclei, ...

Etc., etc. --> https://www.google.ru/search?newwindow=1&biw=1045&bih=730&tb...


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Note added at 20 мин (2020-09-17 12:35:29 GMT)
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Though apoptotic figures are used as well -> https://www.google.ru/search?newwindow=1&biw=1045&bih=730&tb...
Peer comment(s):

agree Anton Konashenok : features, patterns
6 hrs
Thank you, Anton!
agree Igor Andreev : apoptotic figures - так бы и оставил, поскольку это подразумевает цитологический анализ, features же могут быть как биохимические - активность ферментов, деградация ДНК (нуклеосомная лесенка на форезе) и т.п.
7 hrs
Thank you, Igor! Now I am also for 'figures'.
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4 KudoZ points awarded for this answer. Comment: "Thank you, Oleg. I'm for 'figures' too, so I'll use this for the glossary."
1 hr

apoptosis characteristics

Creative Biolabs combines three individual assays and builds up a novel analysis system. This triple-endpoint assay is capable of simultaneously evaluate cell viability, cytotoxicity, and - apoptosis characteristics, thus allowing more comprehensive data to uncover the exact mechanism.
https://www.creative-biolabs.com/drug-discovery/therapeutics...
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