English to Russian Medical Medical: Pharmaceuticals

It has long been observed that individuals who inherit the T119M trans-suppressor mutation along with the highly penetrant, pathogenic V30M mutation either do not develop disease or develop disease at a much slower rate (Coelho 1993, Coelho 1996, Hammarström 2002, Berk 2013 ).
The T119M variant tetramer has been shown to dissociate into dimers and monomers 33-fold more slowly than the wild-type tetramer, and the structural basis for this observation has been explored through X-ray crystallography and kinetic studies.
The second line of evidence supporting AG10’s therapeutic potential comes from structural biology data that led to its structure-based drug design.
The super-stabilizing effect of the T119M amino acid substitution has been attributed to unique hydrogen bonds that form between adjacent serine residues at position 117 contributed by individual TTR monomers **deep in the TTR binding pocket**.
These serine residues are brought close enough together (