Glossary entry

German term or phrase:

nach Spiegel

English translation:

according to levels

Added to glossary by Jessica Klingberg
Apr 26, 2018 01:04
6 yrs ago
7 viewers *
German term

nach Spiegel

German to English Medical Medical: Pharmaceuticals Prescription of pharmaceuticals
This comes from a medical report:

- Unverzüglich erfolgte bei V.a. PD-assoziierte Peritonitis die Einleitung einer dualen i.p. Antibiose mit Vancomycin und Gentamycin, nach Spiegel.

- Vancomycin hydrochlorid z.B. VANCOMYCIN Eberth 1 g Troc, i.p. nach Spiegel

- Gentamicin sulfat, z.B. REFOBACIN 80 Injektionslös, i.p. nach Spiegel

Thank you for your help.

Discussion

Herbmione Granger May 1, 2018:
Hi Jessica Thank you for acknowledging part of my concerns.
I'm pretty sure that this phrase is short for "(Dosierung) nach Spiegelbestimmung" because of its usage.
Similar to my usage of "in quotes" below - a very informal version of "in quotation marks," or in British English "in inverted commas."
Jessica Klingberg (asker) Apr 29, 2018:
herbalchemist, I apologize for not mentioning you or David Hollywood in my final message. I was distracted. Thank you to everyone for your valuable contributions, they are all appreciated and they all helped me to come to a decision as to how to translate this term.
Herbmione Granger Apr 29, 2018:
apologize for not being helpful I thought I could be, since I have experience handling prescriptions and pharmaceuticals in the US.
Herbmione Granger Apr 28, 2018:
"nach Spiegel" A literal translation is usually not good for a phrase often in quotes, especially if the target language is not "European" English.
http://www.kh-cirs.de/faelle/juli15.html
https://static-content.springer.com/esm/art:10.1007/s00063-0...

Suggestion: "with therapeutic monitoring"
https://medicine.stonybrookmedicine.edu/system/files/SBUH Va...
http://medicalstaff.fraserhealth.ca/getattachment/Clinical-R...
https://www.idsociety.org/uploadedFiles/IDSA/Guidelines-Pati...

In line with andres-larsen's references under "therapeutic drug monitoring TDM > Arzneimittelspiegelbestimmung"
Another one: https://epub.uni-regensburg.de/28552/1/Dissertation_Onlineve...

Proposed translations

+3
2 hrs
Selected

according to level

Gentamicin and vancomycin are antibiotics whose blood level (concentration) may need to be monitored:
"Patients with a creatinine clearance of <20ml/min should have gentamicin levels taken every 48 hours, and receive their next dose when levels fall to <1mg/L."
https://www.pharmaceutical-journal.com/learning/learning-art...
Peer comment(s):

agree Marga Shaw : 'Continue IP Vancomycin and Gentamicin according to levels.' www.meht.nhs.uk/EasysiteWeb/getresource.axd?AssetID=13420&t...
4 hrs
Many thanks, Marga.
agree Anne Schulz
5 hrs
Many thanks, Anne.
agree Elif Baykara Narbay
13 hrs
Many thanks, Elif.
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "This is the answer I chose to use, although I'd still like to thank andres-larsen for his valuable contribution."
35 mins

according to/in line with medical records

not sure if this works but might get the ball rolling

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Note added at 36 mins (2018-04-26 01:41:07 GMT)
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not much more than a guess here

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Note added at 1 hr (2018-04-26 02:28:54 GMT)
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"medical records on file" at a stretch

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Note added at 1 hr (2018-04-26 02:29:22 GMT)
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but I'm guessing
Something went wrong...
+1
2 days 16 hrs

subject to [gentamicin / vancomycin] concentrations / levels [therapeutic drug] monitoring <TDM>

in line with Lancashireman:

subject to [gentamicin / vancomycin] concentrations / levels [therapeutic drug] monitoring <TDM>

sources:

The Role of Monitoring Gentamicin Levels in Patients ... - ResearchGate
https://www.researchgate.net/.../259566864_The_Role_of_Monit...
Dec 21, 2017 - Full-text (PDF) | There is limited available evidence regarding the role of monitoring serum gentamicin concentrations in peritoneal dialysis (PD) patients receiving this ... In 17 (26%) patients receiving extended gentamicin therapy, day-5 gentamicin levels were not significantly related to peritonitis cure.

The role of monitoring vancomycin levels in patients with peritoneal ...
europepmc.org/articles/pmc4406318
S Stevenson - ‎2015 - ‎
Keywords: Kidney failure, chronic outcomes, peritoneal dialysis, peritonitis, therapeutic drug monitoring, vancomycin ... When antibiotics are administered intermittently via the IP route, ongoing effective eradication of peritoneal organisms during non-antibiotic PD exchanges requires back-diffusion of drug from the serum ...

The Role of Monitoring Gentamicin Levels in Patients with Gram ...
www.pdiconnect.com/content/34/2/219.abstract
W Tang - ‎2014 - ‎
Background: There is limited available evidence regarding the role of monitoring serum gentamicin concentrations in peritoneal dialysis (PD) patients ... between measured serum gentamicin levels on day 2 following initial empiric antibiotic therapy and subsequent clinical outcomes of confirmed gram-negative peritonitis.

Intraperitoneal Vancomycin Concentrations During Peritoneal Dialysis ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525447/
R Fish - ‎2012 - ‎
Reagents from Roche Diagnostics (Mannheim, Germany) for online therapeutic drug monitoring were used for vancomycin measurements, and the assay was run on the Roche Modular Analytics P module platform. The sampling system uses capacitance liquid level sensing technology. The reagents consisted of 2 ...

Therapeutic drug monitoring of antimicrobials - NCBI - NIH
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248253/
JA Roberts - ‎2012 - ‎
Therapeutic drug monitoring of aminoglycosides (e.g. gentamicin, tobramycin and amikacin) has become standard clinical practice. Whilst the purpose of this .... Monitoring of vancomycin peak concentration is no longer considered necessary given the strong correlation between trough concentrations and AUC0–24/MIC.

Therapeutic drug monitoring - Public Health Ontario
https://www.publichealthontario.ca/.../ASP_Strategy_Therapeu...
infective therapeutic drug monitoring involves aminoglycosides (e.g., gentamicin, tobramycin, amikacin) and vancomycin. There are definite associations between toxicity and aminoglycoside trough serum levels and between therapeutic efficacy and peak serum levels.1. Patients on aminoglycoside therapy should have ...
Peer comment(s):

agree Lancashireman : At 27 mins. Duplicated at 2 hrs.
5 mins
Thanks, Lancashireman, you are right!
Something went wrong...

Reference comments

27 mins
Reference:

therapeutic drug monitoring TDM > Arzneimittelspiegelbestimmung

The Role of Monitoring Gentamicin Levels in Patients ... - ResearchGate
https://www.researchgate.net/.../259566864_The_Role_of_Monit...
Dec 21, 2017 - Full-text (PDF) | There is limited available evidence regarding the role of monitoring serum gentamicin concentrations in peritoneal dialysis (PD) patients receiving this ... In 17 (26%) patients receiving extended gentamicin therapy, day-5 gentamicin levels were not significantly related to peritonitis cure.

The role of monitoring vancomycin levels in patients with peritoneal ...
europepmc.org/articles/pmc4406318
S Stevenson - ‎2015 - ‎
Keywords: Kidney failure, chronic outcomes, peritoneal dialysis, peritonitis, therapeutic drug monitoring, vancomycin ... When antibiotics are administered intermittently via the IP route, ongoing effective eradication of peritoneal organisms during non-antibiotic PD exchanges requires back-diffusion of drug from the serum ...

The Role of Monitoring Gentamicin Levels in Patients with Gram ...
www.pdiconnect.com/content/34/2/219.abstract
W Tang - ‎2014 - ‎
Background: There is limited available evidence regarding the role of monitoring serum gentamicin concentrations in peritoneal dialysis (PD) patients ... between measured serum gentamicin levels on day 2 following initial empiric antibiotic therapy and subsequent clinical outcomes of confirmed gram-negative peritonitis.

Intraperitoneal Vancomycin Concentrations During Peritoneal Dialysis ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525447/
R Fish - ‎2012 - ‎
Reagents from Roche Diagnostics (Mannheim, Germany) for online therapeutic drug monitoring were used for vancomycin measurements, and the assay was run on the Roche Modular Analytics P module platform. The sampling system uses capacitance liquid level sensing technology. The reagents consisted of 2 ...

dict.cc Wörterbuch :: therapeutic drug monitoring :: Deutsch-Englisch ...
https://www.dict.cc/englisch.../therapeutic drug monitoring....
Übersetzung(en) tabellarisch anzeigen | immer » Übersetzungen mit gleichem Wortanfang » therapeutic | drug | monitoring · therapeutic drug monitoring <TDM> · Arzneimittelspiegelbestimmung {f} med. therapeutisches Drug-Monitoring {n} <TDM> med. Medikamentenspiegelbestimmung {f} med. pharm.

TDM - Therapeutic Drug Monitoring ... - Labor Lademannbogen
www.labor-lademannbogen.de/analysen/analysen-spektrum/.../t...
TDM. Therapeutic Drug Monitoring, Medikamentenspiegelbestimmung, Drug Monitoring. Material. je nach Wirkstoff und Fragestellung: - Serum/Plasma. - EDTA-Blut. - Sonstige. Klinische Relevanz. - Individuelle Dosisanpassung mit dem Ziel optimaler Wirkspiegel. - Unterversorgung / Wirkverlust erkennen. - Überdosierung ...

Therapeutisches Drug Monitoring (TDM) - Labor Lademannbogen
www.labor-lademannbogen.de/.../therapeutisches-drug-monitor...
Das Therapeutische Drug Monitoring (TDM) ist die Bestimmung von Konzentrationen (Spiegel) von therapeutisch verabreichten Substanzen (Arzneimitteln) in ... Nach Medikationsbeginn und auch nach jeder Dosis-Änderung müssen mindestens 4-5 Halbwertszeiten vergangen sein, bis dieser Zustand erreicht ist.

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Note added at 34 mins (2018-04-26 01:38:53 GMT)
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Therapeutic drug monitoring of antimicrobials - NCBI - NIH
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248253/
JA Roberts - ‎2012 - ‎
Therapeutic drug monitoring of aminoglycosides (e.g. gentamicin, tobramycin and amikacin) has become standard clinical practice. Whilst the purpose of this .... Monitoring of vancomycin peak concentration is no longer considered necessary given the strong correlation between trough concentrations and AUC0–24/MIC.

Therapeutic drug monitoring - Public Health Ontario
https://www.publichealthontario.ca/.../ASP_Strategy_Therapeu...
infective therapeutic drug monitoring involves aminoglycosides (e.g., gentamicin, tobramycin, amikacin) and vancomycin. There are definite associations between toxicity and aminoglycoside trough serum levels and between therapeutic efficacy and peak serum levels.1. Patients on aminoglycoside therapy should have ...

Therapeutisches Drug-Monitoring (TDM) - Roche Diagnostics
www.roche-diagnostics.ch/.../02TDM-Therapeutic-drug-monitor...
TDM: vom therapeutischen Drug-Monitoring hin zum thera- peutischen .... gende Nebenwirkungen herbeiführen: Antiasthmatika. Theophyllin. Antibiotika. Amikacin. Gentamicin. Vancomycin. Tobramycin. Antimanika. Carbamazepin. Lithium ..... Der C2-Spiegel, zwei Stunden nach Verabreichung von Cyclospo- rin, stellt den ...

TDM-Handbuch IKP HRO 2016 - Institut für Klinische Pharmakologie
https://ipharma.med.uni-rostock.de/.../TDM-Handbuch_IKP_HRO_...
Mar 1, 2016 - 1.3.2 TDM-Eilanalytik: Eil- und Notfallproben für die Analyten der TDM-Routineanalytik - 5 - ..... Vancomycin-Talspiegel. EDTA 2 ml ... Antibiotika. Gentamicin. 1). 15 - 25 mg/l. Maximum 0,5 h nach Ende der. Infusion über 0,5 h. < 1 mg/l. Minimum direkt vor nächster Dosis. Tobramycin. 1). 15 - 25 mg/l.

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Note added at 36 mins (2018-04-26 01:40:50 GMT)
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Therapeutisches Drug-Monitoring von Antibiotika - Hygel
www.hygel.de/.../Therapeutisches_Drug-Monitoring_von_Antibi...
Apr 24, 2014 - Therapeutisches Drugmonitoring (TDM) von Antibiotika ist bereits ... Spiegelkontrolle nach Erreichen des vermuteten Steady-State ... Piperacillin (auch anzufordern bei. Gabe von Piperacillin/Tazobactam. (Tazobac®)). ▻ Meropenem. ▻ Tobramycin. ▻ Gentamicin. ▻ Vancomycin. ▻ Fosfomycin. Messung ...
Peer comments on this reference comment:

agree Lancashireman : level/concentrations: you should have posted this as an answer
12 hrs
Thanks, Lancashireman, I will!
Something went wrong...
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